Anti-GAPDH antibodies are used in the immunodetection of the enzyme glyceraldehyde-3-phosphate dehydrogenase. Encoded by the GAPDH gene, this enzyme plays a central role in glycolysis by catalyzing D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. GAPDH is also a component of the GAIT (gamma interferon-activated inhibitor of translation) complex and exhibits nitrosylase activity. As a constitutively expressed housekeeping gene, GAPDH is among the most commonly used loading control proteins for immunodetection applications like Western blot. Over 10,000 citations in the literature have described the use of GAPDH antibodies in research. GAPDH gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Visit the supplier page for more information, including target specificity and validated applications.