Good Loading Control GAPDH Antibody from CST

LMP
University of Toronto
Graduate Student

Overall

Quality of Results

Ease-of-Optimization

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Company:

Cell Signaling Technology

Product Name:

GAPDH Ab

Catalog Number:

5014

Clone Number:

14C10

Loading control antibodies are crucial when assessing the expression level of proteins through WB. Here, I utilized the GAPDH antibody as a loading control in acute myeloid leukemia cell line OCI AML-2 to determine if I generated a KO of my protein of interest (USP22).

Experimental Design and Results Summary

Applications

Western Blot

Sample

AML2 whole cell lysate

Primary Incubation

1:3000 RT 1hr in 5% skim milk

Blocking Agent

5% milk - 10 min room temperature

Secondary Incubation

5% milk - 30 min room temperature secondary Ab 1:10K

Tertiary Incubation

N/A

Detection

ECL - film

Results Summary

Good antibody for western blot with no background. Approx. size 38 kDa. Conditions represent samples following CRISPR/Cas9 mediated deletion of USP22. sgLacZ represents non-targeting control. GAPDH is shown as the loading control.

DOI or PMID #

N/A

Additional Notes

N/A

Related Categories

Image Gallery

Summary

The Good

Works well even at 1:3K dilution.

The Bad

N/A

The Bottom Line

Good loading control Ab for WB

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