Anti-PDCD1 antibodies are used in the immunodetection of the protein programmed cell death 1. In humans, the canonical protein has a reported length of 288 amino acid residues and a mass of 31.6 kDa. Its subcellular localization is in the cell membrane. It is notably expressed in the lymph node and tonsil. PDCD1 is known to be involved with adaptive immune responses and the apoptotic pathway. Post-translational modifications have been described, including N-glycosylation, ubiquitination and phosphorylation.
The PDCD1 marker can be used to identify T Follicular Helper Cells and T Follicular Regulatory Cells.* Synonyms for this target antigen include PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1, programmed cell death protein 1, and CD279. PDCD1 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. Over 4400 citations in the literature describe the use of PDCD1 antibodies in research. Flow Cytometry is a widely used application for these antibodies. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4