Fig 1: Comparative ligand expression and pan-cancer analysis for TIM-3 and OX40. TCGA Pan Cancer Atlas Cohort was employed to examine mRNA expression [log2(value+1)] of (A) TIM-3 (B) OX40 and (C) PD-1 across select cancer subtypes. (D) Galectin-9, OX40L and PD-L1 average transcript expression (FKPM) from the TCGA ovarian cancer cohort. TCGA ovarian cancer cohort analysis of (E) OX40L (F) PD-L1 and (G) Galectin-9 mRNA expression (-log10) stratified by median overall survival. *P<0.005 as indicated. NS, not significant; TCGA, The Cancer Genome Atlas; ccRCC, clear cell renal cell carcinoma; pRCC, papillary renal cell carcinoma; PD-1, programmed cell death protein-1.