Anti-PTPRC antibodies are used in the immunodetection of the protein protein tyrosine phosphatase receptor type C. In humans, the canonical protein has a reported length of 1306 amino acid residues and a mass of 147.5 kDa. Its subcellular localization is in the cell membrane. Up to 8 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the appendix and bone marrow. A member of the Protein-tyrosine phosphatase protein family, PTPRC is known to be involved with B cell differentiation and receptor-mediated signaling pathways. Post-translational modifications have been described, including O-glycosylation.
The PTPRC marker can be used to identify Alveolar Macrophages CCL3+ Cells, Alveolar Macrophages, Alveolar Macrophages Proliferating Cells, Alveolar Macrophages Mt+ Cells, and Interstitial Macrophages.* Synonyms for this target antigen include CD45, CD45R, GP180, IMD105, L-CA, LCA, LY5, and B220. PTPRC gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4