Anti-Interleukin 7 antibodies are used for the immunodetection of the protein encoded by the IL7 gene. In humans, the canonical protein has a reported length of 177 amino acid residues and a mass of 20.2 kDa. It is known to be a secreted protein. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of the IL-7/IL-9 protein family, it is reported to be a hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis. Post-translational modifications have been described, including glycosylation.
The interleukin 7 marker can be used to characterize T Cells Zone Reticular Cells and Fibroblastic Reticular Cells (FRC).* Gene orthologs have been identified in the mouse, rat, bovine and chimpanzee species. Over 110 citations in the literature describe the use of Interleukin 7 antibodies in research. ELISA and Western Blot are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4