Anti-CD3D antibodies are used in the immunodetection of the protein CD3 delta subunit of T-cell receptor complex. In humans, the canonical protein has a reported length of 171 amino acid residues and a mass of 18.9 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the tonsil, thymus, and kidney. CD3D is known to be a part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. Post-translational modifications have been described, including phosphorylation and glycosylation.
The CD3D marker can be used to identify CD4 Naïve Cells, CD4 Memory T Cells, Effector Memory CD45RA CD4 T Cells, CD8 Naïve Cells, and CD8 Effector Memory T Cells.* Synonyms for this target antigen include CD3DELTA, IMD19, T3D, T-cell surface glycoprotein CD3 delta chain, CD3 antigen, delta subunit, and CD3-DELTA. CD3D gene orthologs have been reported in the mouse, bovine and chimpanzee species. Over 8600 citations in the literature describe the use of CD3D antibodies in research. These antibodies are most commonly used in Flow Cytometry experiments, among other applications.
*HuBMAP Human Reference Atlas v1.4