Anti-KLRG1 antibodies are used in the immunodetection of the protein killer cell lectin like receptor G1. In humans, the canonical protein has a reported length of 195 amino acid residues and a mass of 21.8 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is noted to be expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells. KLRG1 is known to play an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. Post-translational modifications have been described, including glycosylation. The KLRG1 marker can be used to identify Mature CD8 T Cells and Mucosal Invariant T Cells.* Synonyms for this target antigen include CLEC15A, MAFA, MAFA-2F1, MAFA-L, MAFA-LIKE, and 2F1. KLRG1 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4