Anti-Forkhead Box P3 antibodies are used for the immunodetection of the protein encoded by the FOXP3 gene. In humans, the canonical protein has a reported length of 431 amino acid residues and a mass of 47.2 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 4 different isoforms for this protein. It is a reported transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Post-translational modifications have been described, including ubiquitination, acetylation, protein cleavage and phosphorylation.
The forkhead box P3 marker can be used to characterize Regulatory T Cells, Large Intestine Lamina Propria Lymphocytes, Cytotoxic T Cells, T Follicular Regulatory Cells, and T Regulatory Cells.* Other names for this target antigen include DIETER, IPEX, JM2, PIDX, XPID, forkhead box protein P3, FOXP3delta7, and AIID. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish and chimpanzee species. Over 7700 citations in the literature describe the use of Forkhead Box P3 antibodies in research. Flow Cytometry, Western Blot, and Immunohistochemistry are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4