Anti-CD86 antibodies are used in the immunodetection of the protein CD86 molecule. In humans, the canonical protein has a reported length of 329 amino acid residues and a mass of 37.7 kDa. Its subcellular localization is in the cell membrane. Up to 6 different isoforms have been reported for this protein. It is noted to be expressed by activated B-lymphocytes and monocytes. CD86 is a known receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. Post-translational modifications have been described, including ubiquitination and glycosylation. The CD86 marker can be used to identify CD1C+ Myeloid Dendritic Cells.* Synonyms for this target antigen include B7.2, B70, CD28LG2, LAB72, T-lymphocyte activation antigen CD86, B-lymphocyte activation antigen B7-2, BU63, and B7-2. CD86 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4