Measuring CD86 Expression

Immunology
University of Rochester
Graduate Student

Overall

Quality of Results

Ease-of-Optimization

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Company:

BioLegend

Product Name:

CD86 percp

Catalog Number:

105025

A spleen was harvested from a C57BL/6 mouse and a single cell suspension was made.  The cells were stained with the antibody that I am reviewing and also stained with an anti-mouse CD11c antibody.  For data analysis, I gated on the CD11c positive population and assessed expression levels on a histogram for the antibody that I am reviewing. This ab was used to measure CD86 maturation marker expression on mouse dendritic cells from the spleen.

Experimental Design and Results Summary

Applications

Flow Cytometry

Sample

Mouse splenocytes

Primary Incubation

1:200 on ice for 20min.

Blocking Agent

Fc Block

Secondary Incubation

NA

Tertiary Incubation

NA

Detection

Flow cytometry

Results Summary

The antibody stains intermediate and high CD86 expressors.

Additional Notes

None

Related Categories

Image Gallery

Summary

The Good

Can be easily titrated

The Bad

Fluorochrome chosen may bleed over other channels

The Bottom Line

This antibody can stain cells brightly.

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