What are CD11c antibodies?
Anti-CD11c antibodies are immunoglobulins that specifically recognize and bind CD11c, an integrin alpha subunit also known as ITGAX that is expressed predominantly on dendritic cells and macrophages. These antibodies are used for immunodetection across general sample types such as tissue samples, cell lysates, and cultured cells. CD11c pairs with integrin beta-2 to form a fibrinogen receptor important in monocyte adhesion, and it is a standard marker for identifying dendritic cell populations by flow cytometry.
Catalog highlights and purchasing considerations
About the Biocompare CD11c catalog
The Biocompare antibody search tool lists anti-CD11c antibodies from a range of suppliers, spanning polyclonal and monoclonal formats validated across multiple applications. Sample listings also reference the alternate gene symbol ITGAX. Flow cytometry, immunohistochemistry, and western blot are the most common validated applications among these products.
Considerations when choosing a CD11c antibody for research
Confirm that the antibody's intended target is accurate, as many genes carry synonym symbols that can create ambiguity across suppliers. Specificity should be verified against the immunogen sequence or region listed on the product datasheet, since antibodies raised against different epitopes of the same protein can behave differently across applications. Beyond specificity, several target-related attributes can affect antibody binding, including subcellular location, extracellular and cytoplasmic domain boundaries for membrane-associated targets, tissue specificity, post-translational modifications, and the presence of additional isoforms or disease-associated variants. In parallel, antibody-specific selection criteria include clonality (monoclonal versus polyclonal), host species, species reactivity, and the choice of conjugate or label suited to the intended detection method. Supplier-provided validation data, such as western blot bands at the expected molecular weight, immunohistochemistry staining patterns consistent with known tissue distribution, or knockout and knockdown controls, is widely regarded as the most reliable final check before purchase.