Anti-CD44 antibodies are used in the immunodetection of the protein CD44 molecule (Indian blood group). In humans, the canonical protein has a reported length of 742 amino acid residues and a mass of 81.5 kDa. Its subcellular localization is in the cell membrane and is secreted. Up to 19 different isoforms have been reported for this protein. It is notably expressed in fibroblasts and urine. CD44 is reported to be a cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Post-translational modifications have been described, including O-glycosylation, N-glycosylation, protein cleavage, sulfation and phosphorylation.
The CD44 marker can be used to identify Cells Large Intestine Intestinal Crypt Stem Cells, CD4+ Resident Memory T Cells, Wharton's Jelly Mesenchymal Stromal Cells, Amnion Mesenchymal Stromal Cells (AMSC), and Chorionic Mesenchymal Stromal Cells (CMSC).* Synonyms for this target antigen include CSPG8, ECM-III, ECMR-III, H-CAM, HCELL, HUTCH-1, HUTCH-I, and CDW44. CD44 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4