Anti-FOXP3 antibodies are used in the immunodetection of the protein forkhead box P3. In humans, the canonical protein has a reported length of 431 amino acid residues and a mass of 47.2 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 4 different isoforms have been reported for this protein. It is notably expressed in the tonsil, spleen, lymph node, lung, and appendix. FOXP3 is a reported transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Post-translational modifications have been described, including ubiquitination, acetylation, protein cleavage and phosphorylation.
The FOXP3 marker can be used to identify Regulatory T Cells, Large Intestine Lamina Propria Lymphocytes, Cytotoxic T Cells, T Follicular Regulatory Cells, and T Regulatory Cells.* Synonyms for this target antigen include DIETER, IPEX, JM2, PIDX, XPID, forkhead box protein P3, FOXP3delta7, and AIID. FOXP3 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4