Anti-ITGAX antibodies are used in the immunodetection of the protein integrin subunit alpha X. In humans, the canonical protein has a reported length of 1163 amino acid residues and a mass of 127.8 kDa. Its subcellular localization is in the membrane. It is reported to be highly expressed in the monocytes and granulocytes. A member of the Integrin alpha chain protein family, ITGAX is known to be involved with organ morphogenesis and cell adhesion. Post-translational modifications have been described, including glycosylation. The ITGAX marker can be used to identify Brain Microglia, Dendritic Cells, Large Intestine Lamina Propria Lymphocytes, Lymph Node Subcapsular Sinus Macrophages, and Macrophages.* Synonyms for this target antigen include SLEB6, integrin alpha-X, CD11 antigen-like family member C, complement component 3 receptor 4 subunit, and CD11C. ITGAX gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4