Anti-MKI67 antibodies are used in the immunodetection of the protein marker of proliferation Ki-67. In humans, the canonical protein has a reported length of 3256 amino acid residues and a mass of 358.7 kDa. Its subcellular localization is in the nucleus and chromosomes. Up to 2 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the bone marrow and lymph node. MKI67 is known to be required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly.
The MKI67 marker can be used to identify Centrocytes, Centroblasts, Granular Keratinocytes, and Basal Keratinocytes.* Synonyms for this target antigen include MIB-, MIB-1, PPP1R105, proliferation marker protein Ki-67, Molecular Immunology Borstel antibody 1, and KIA. MKI67 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 7900 citations in the literature describe the use of MKI67 antibodies in research. Immunohistochemistry is a widely used application for these antibodies. Flow Cytometry, Western Blot, and Immunofluorescence are also common applications.
*HuBMAP Human Reference Atlas v1.4