Anti-ITGA4 antibodies are used in the immunodetection of the protein integrin subunit alpha 4. In humans, the canonical protein has a reported length of 1032 amino acid residues and a mass of 114.9 kDa. Its subcellular localization is in the membrane. Up to 2 different isoforms have been reported for this protein. A member of the Integrin alpha chain protein family, ITGA4 is known to be involved with B cell differentiation and cell adhesion. Post-translational modifications have been described, including phosphorylation and glycosylation. The ITGA4 marker can be used to identify Hippocampal Gyrus CA1-3 Neurons and Hippocampal Gyrus CA4 Neurons.* Synonyms for this target antigen include IA4, integrin alpha-4, 269C wild type, CD49 antigen-like family member D, VLA-4 subunit alpha, and CD49D. ITGA4 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4