Anti-SOX9 antibodies are used in the immunodetection of the protein SRY-box transcription factor 9. In humans, the canonical protein has a reported length of 509 amino acid residues and a mass of 56.1 kDa. Its subcellular localization is in the nucleus. It is notably widely expressed in many tissue types. SOX9 is reported to be a transcription factor that plays a key role in chondrocytes differentiation and skeletal development. Post-translational modifications have been described, including ubiquitination, sumoylation, acetylation and phosphorylation. The SOX9 marker can be used to identify Cells Large Intestine Intestinal Crypt Stem Cells, Hepatic Progenitor Cells, and Follicular Dendritic Cells (FDC).* Synonyms for this target antigen include CMPD1, SRA1, SRXX2, SRXY10, transcription factor SOX-9, and CMD1. SOX9 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4