Anti-HIF-1A antibodies are used in antigen-specific immunodetection in biological samples. The target HIF-1A is a known alias name of the protein hypoxia inducible factor 1 subunit alpha, encoded by the HIF1A gene in humans. This 826-amino acid residue protein is known to function as a master transcriptional regulator of the adaptive response to hypoxia. It is localized to the nucleus and cytoplasm of the cell and features glycosylated, ubiquitinated, sumoylated, acetylated and phosphorylated post-translational modifications. In terms of tissue expression, it is reported to be expressed in most tissues with highest levels in the kidney and heart. Other synonyms for HIF-1A include HIF-1-alpha, HIF-1-alpha, and HIF-1alpha. Over 200 citations in the literature describe the use of HIF-1A antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.