Fig 1: Knockdown of SLC16A3 attenuates IL-8 secretion via HIF-1a. (A) TIMER database showed SLC16A3 was positively relevant to IL-1β, IL-6, IL-8 but negatively to IL-33 in LUAD. (B) Interleukin level was detected with ELISA in A549 cells. SLC16A3 knockdown led to significant IL-8 secretion. (C) TIMER database indicated that SLC16A3 had positive relationship with HIF-1a and flow cytometry result showed SLC16A3 knockdown resulted in decreased HIF-1a expression. (D) DMOG stimulated HIF-1a expression and restored IL-8 level in SLC16A3 downregulated cells. Data were present with mean± SD, * P < 0.05.