Anti-MAPK activated protein kinase 3 antibodies are used for the immunodetection of the protein encoded by the MAPKAPK3 gene. In humans, the canonical protein has a reported length of 382 amino acid residues and a mass of 43 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is found to be widely expressed, with a higher expression level observed in the heart and skeletal muscle. A member of the CAMK Ser/Thr protein kinase protein family, it is known to be involved with intracellular signal transduction and peptidyl-serine phosphorylation. Post-translational modifications have been described, including phosphorylation. The gene encoding this protein is implicated in Macular dystrophy. Other names for this target antigen include MAPKAP3, MDPT3, MK-3, MK3, MAP kinase-activated protein kinase 3, MAPKAP kinase 3, chromosome 3p kinase, and 3PK. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.