Anti-VCAM1 antibodies are used in the immunodetection of the protein vascular cell adhesion molecule 1. In humans, the canonical protein has a reported length of 739 amino acid residues and a mass of 81.3 kDa. Its subcellular localization is in the cell membrane and is secreted. Up to 3 different isoforms have been reported for this protein. It is noted to be expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. VCAM1 is known to be involved with pathways of aging and B cell differentiation. Post-translational modifications have been described, including glycosylation, ubiquitination and protein cleavage.
The VCAM1 marker can be used to identify Parietal Epithelial Cells, Descending Thin Limb Cells, and Follicular Dendritic Cells.* Synonyms for this target antigen include INCAM-100, vascular cell adhesion protein 1, CD106 antigen, and CD106. VCAM1 gene orthologs have been reported in the mouse, rat, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4