Anti-NCAM1 antibodies are used in the immunodetection of the protein neural cell adhesion molecule 1. In humans, the canonical protein has a reported length of 858 amino acid residues and a mass of 94.6 kDa. Its subcellular localization is in the cell membrane and is secreted. Up to 6 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the appendix and cerebellum. NCAM1 is known to be a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.; (Microbial infection) Acts as a receptor for rabies virus. Post-translational modifications have been described, including glycosylation.
The NCAM1 marker can be used to identify Medullary Fibroblasts, Schwann Cells, Large Intestine Lamina Propria Lymphocytes, Lymphatic Vessel Endothelial Cells, and CD56 Bright Natural Killer Cells.* Synonyms for this target antigen include MSK39, NCAM, antigen recognized by monoclonal antibody 5.1H11, neural cell adhesion molecule, NCAM, and CD56. NCAM1 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4