Anti-CDH1 antibodies are used in the immunodetection of the protein cadherin 1. In humans, the canonical protein has a reported length of 882 amino acid residues and a mass of 97.5 kDa. Its subcellular localization is in the Golgi and cell membrane. Up to 2 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. CDH1 is known to be involved with cell adhesion. Post-translational modifications have been described, including O-glycosylation, N-glycosylation, ubiquitination, protein cleavage and phosphorylation.
The CDH1 marker can be used to identify Descending Thin Limb Cells, Ascending Thin Limb Cells, Thick Ascending Limb Cells, Cortical Thick Ascending Limb Cells, and Medullary Thick Ascending Limb Cells.* Synonyms for this target antigen include BCDS1, CD324, CDHE, ECAD, LCAM, UVO, CAM 120/80, and Arc-1. CDH1 gene orthologs have been reported in the mouse, rat and chimpanzee species. Over 8100 citations in the literature describe the use of CDH1 antibodies in research. Western Blot is a widely used application for these antibodies. Flow Cytometry, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4