Anti-p53 antibodies enable researchers to detect and measure the p53 antigen in biological samples. This target is a reported synonym of the TP53 gene, which encodes tumor protein p53. This protein is known to function in autophagy pathways and the apoptotic pathway, among other biological roles. The human version of p53 has a canonical amino acid length of 393 residues and a protein mass of 43.7 kilodaltons, although 9 isoforms have been identified. It is reported to be localized in the nucleus, mitochondria, ER, and cytoplasm of cells and notably expressed in the rectum, placenta, oral mucosa, esophagus, and colon. The p53 marker has been described in the characterization of Granular Keratinocytes and Basal Keratinocytes.* Other names for this target antigen include BCC7, BMFS5, and LFS1.
*HuBMAP Human Reference Atlas v1.4