What are HSP70 antibodies?
Anti-HSP70 antibodies are immunoglobulins that specifically recognize and bind heat shock 70 kDa protein 1A (HSPA1A), a member of the HSP70 chaperone family in humans. In research applications, these antibodies are used to detect HSP70 in tissue samples, cell lysates, and cultured cells. HSP70 is a molecular chaperone implicated in protecting the proteome from stress, folding and transporting newly synthesized polypeptides, and controlling the targeting of misfolded proteins for degradation. Detecting HSP70 supports research into cellular stress responses and their roles in neurodegeneration, cancer, and reproductive biology.
Catalog highlights and purchasing considerations
About the Biocompare HSP70 antibody catalog
The Biocompare antibody search tool lists anti-HSP70 antibodies from a range of suppliers, spanning unconjugated and fluorophore- or enzyme-conjugated formats. The listing may also include antibodies that cross-react with related heat shock protein family members, such as HSC70 (HSPA8), mitochondrial HSP70 (HSPA9), and HSPA4. Western blot is the most common validated application among these listings, followed by immunohistochemistry and immunofluorescence. Several HSP70 antibodies mentioned here have been cited across a range of stress-response research, including heat stress effects on skeletal muscle proteostasis, AHA1-mediated regulation of amyloid precursor protein processing relevant to Alzheimer's disease, and determinants of human sperm cryoresistance. Antibody reviews written by individual researchers have discussed unique immunodetection studies involving HSP70, such as antibody specificity confirmed against both Hsc70 and Hsp70 without cross-reactivity to other family members.
Considerations when choosing an HSP70 antibody for research
Confirm that the antibody's intended target is accurate, as many genes carry synonym symbols that can create ambiguity across suppliers. Specificity should be verified against the immunogen sequence or region listed on the product datasheet, since antibodies raised against different epitopes of the same protein can behave differently across applications. Beyond specificity, several target-related attributes can affect antibody binding, including subcellular location, extracellular and cytoplasmic domain boundaries for membrane-associated targets, tissue specificity, post-translational modifications, and the presence of additional isoforms or disease-associated variants. In parallel, antibody-specific selection criteria warrant consideration, including clonality (monoclonal versus polyclonal), host species, species reactivity, and conjugate or label choice suited to the detection method. Supplier validation data, such as western blot bands at the expected molecular weight, immunohistochemistry staining patterns consistent with known tissue distribution, and knockout or knockdown controls, should also be carefully reviewed before purchase.