Anti-CD14 antibodies are used in the immunodetection of the protein CD14 molecule. In humans, the canonical protein has a reported length of 375 amino acid residues and a mass of 40.1 kDa. Its subcellular localization is in the Golgi, cell membrane, and is secreted. It is notably expressed in many tissues, such as the colon and endometrium. CD14 is known to be involved with the apoptotic pathway and receptor-mediated signaling pathways. Post-translational modifications have been described, including O-glycosylation. The CD14 marker can be used to identify CD14 Monocytes, Macrophages, Dendritic Cells, Classical Inflammatory Monocytes, and Lymph Node Subcapsular Sinus Macrophages.* Synonyms for this target antigen include monocyte differentiation antigen CD14 and myeloid cell-specific leucine-rich glycoprotein. CD14 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4