Anti-LYN antibodies are used in the immunodetection of the protein LYN proto-oncogene, Src family tyrosine kinase. In humans, the canonical protein has a reported length of 512 amino acid residues and a mass of 58.6 kDa. Its subcellular localization is in the cell membrane, nucleus, Golgi, and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is notably expressed in monocytes. A member of the Tyr protein kinase protein family, LYN is known to be involved with adaptive immune responses and dendritic cell differentiation. Synonyms for this target antigen include p53Lyn, p56Lyn, tyrosine-protein kinase Lyn, lck/Yes-related novel protein tyrosine kinase, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog, and JTK8. LYN gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 1900 citations in the literature describe the use of Lyn antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.