Anti-CD11b antibodies are used in antigen-specific immunodetection in biological samples. The target CD11b is a known alias name of the protein integrin subunit alpha M, encoded by the ITGAM gene in humans. This 1152-amino acid residue protein is known to be involved in the apoptotic pathway and cell adhesion, among other biological processes. It is localized to the cell membrane of the cell and features glycosylated post-translational modifications. In terms of tissue expression, it is reported to be highly expressed in the monocytes and granulocytes. The CD11b marker has been identified in populations of Neutrophils, Dendritic Cells, Mature Eosinophils, Large Intestine Macrophages, and Macrophages.* Other synonyms for CD11b include CR3A and MAC-1. A number of CD11b antibodies have been mentioned in research publications and have associated citations. Flow Cytometry is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.
*HuBMAP Human Reference Atlas v1.4