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Automated DNA/RNA Purification Sample Preparation Workstations
Maxwell RSC Instrument
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Maxwell RSC Instrument
Maxwell RSC Instrument
Maxwell RSC Instrument from Promega
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Citations:
(802)
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(1)
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Maxwell RSC Instrument
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Description
The Maxwell RSC Instrument is a platform for automated extraction of nucleic acid from a range of sample types. Extraction methods use sample lysis and binding to paramagnetic particles followed by washing steps and elution.
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
Maxwell RSC Instrument
Company
Promega
Price
Supplier Page
View Company Product Page
Catalog Number
AS4500
Quantity
EA
Processing Time
30 to 60 min (depending on sample type and method)
Capacity
Up to 16
Dimensions
(WxDxH) 330.2 x 345.2 x 299.7 mm (13 x 13.6 x 11.8 in)
UV Lamp
Avg. lifetime approximately 6,000 hrs
Molecular Weight
~85kDa
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Promega
2800 Woods Hollow Rd
Madison
,
WI
53711
United States
Phone
: Tel: +1 (608) 274-4330
Fax: +1 (608) 277-2516
Email: custserv@promega.com
techserv@promega.com
Company Profile
Website:
http://www.promega.com
Citations (802)
(101)
Inter-Island Whole-Genome Comparison Reveals Micro-Evolutionary Dynamics of the Red Fox, Stimulated Through Post-Glacial Sea-Level Alterations
Genome Biol Evol
August 21, 2025
Takumi Watanabe, Shin Shinojima Satoh, Toshiaki Shiraishi, Shosei Kubota, Yuji Yamazaki
Whole-Genome Sequencing
Genomic DNA (gDNA) was extracted from each sample using an automatic
nucleic acid purification
device
Maxwell RSC Instrument
(
Promega
Corp., Madison, WI, U.S.A.), following the protocol of the
Maxwell RSC Tissue DNA Kit
. Tissues
(102)
Adjuvant anti-PD-1 therapy improves melanoma-specific survival in stage IIIC-IV melanoma patients with high tumor mutation burden and BRAF V600 mutation
Front Oncol
August 12, 2025
Julia Forschner, Julia Huynh, Christopher Schroeder, Sorin Armeanu-Ebinger, Olga Seibel-Kelemen, Axel Gschwind, Irina Bonzheim, Thomas K. Eigentler, Teresa Amaral, Stephan Ossowski,
et al.
DNA was isolated from
tumor
FFPE tissue and blood samples using the
Maxwell® RSC DNA FFPE kit
and the
Maxwell® RSC instrument
(
Promega
, Madison, WI, USA) according to the manufacturer’s standard protocols. After isolation, 200
(103)
LMF1 frameshift deletion in Franches-Montagnes horses with hypertriglyceridemia-induced pancreatitis
Sci Rep
August 6, 2025
Michaela Drögemüller, Nathalie Fouché, Michelle Wyler, Corinne Gurtner, Seraina L. Meister, Markus Neuditschko, Vidhya Jagannathan, Vinzenz Gerber, Tosso Leeb
DNA was extracted from EDTA blood using the
Maxwell RSC Whole Blood DNA kit
in combination with the
Maxwell RSC instrument
(
Promega
, Dübendorf, Switzerland). The same instrument was used for DNA isolation from
formalin-fixed paraffin-embedded
(104)
Detecting actionable mutations from matched plasma-based versus tissue next-generation sequencing in advanced non-small cell lung cancer: a retrospective single centre analysis on site
J Exp Clin Cancer Res
August 6, 2025
Christophe Bontoux, Caroline Lacoux, Jonathan Benzaquen, Jacques Boutros, Guylène Rignol, Elodie Long-Mira, Sandra Lassalle, Maryline Allegra, Doriane Bohly, Mathieu Garcia,
et al.
cytological specimens and surgically resected specimens, using the
Maxwell RSC Instrument
(
Promega
, #
AS4500
) with the
Maxwell RSC FFPE Plus DNA Kit
(#
AS1720
) and
Maxwell RSC RNA FFPE Kit
(#
AS1440
). Extracted
(105)
Comprehensive genetic profiling using tissue and blood in locally advanced tumors
Oncol Rep
August 5, 2025
Kenji Fujiyoshi, Rie Sugihara, Naoki Miyamoto, Yoriko Watanabe, Tomoya Sudo, Sanae Numata, Jun Akiba, Hideyuki Abe, Yuka Ichinose, Kenji Inoue,
et al.
quantification DNA and RNA from FFPE tissue specimens were extracted using a
Maxwell RSC Instrument
(cat. no.
AS4500
;
Promega
, Corp.),
Maxwell RSC FFPE Plus DNA kit
(cat. no.
AS1720
;
Promega
, Corp.) and
Maxwell RSC RNA FFPE kit
(106)
Accurate genotyping of three major respiratory bacterial pathogens with ONT R10.4.1 long-read sequencing
Genome Research
August 1, 2025
Nora Zidane, Carla Rodrigues, Valérie Bouchez, Martin Rethoret-Pasty, Virginie Passet, Sylvain Brisse, Chiara Crestani
standardized conditions, as previously described (Bouchez et al. 2018). DNA extraction was performed on a
Maxwell RSC instrument
(
Promega
) with the
Maxwell RSC Blood DNA Kit
(
Promega
) following the manufacturer's instructions. Library
(107)
FGFR4 p.Gly388Arg polymorphism in PBMCs of LAM patients: findings of a pilot study
Frontiers in Medicine
July 24, 2025
Sinem Koc-Gunel, Amy L. Ryan, Melanie Winter, Thomas O. F. Wagner
platelets
and Ficoll. DNA extraction and quantification Genomic DNA was (13) extracted using the
Maxwell® RSC Instrument
(
Promega Corporation
, Madison, Wisconsin, United States) with the
Maxwell® RSC FFPE Plus DNA Kit
(
Promega Corporation
(108)
Identifying Genetic Variations in emm89 Streptococcus pyogenes Associated with Severe Invasive Infections
Elife
July 24, 2025
Masayuki Ono, Masaya Yamaguchi, Daisuke Motooka, Yujiro Hirose, Kotaro Higashi, Tomoko Sumitomo, Tohru Miyoshi-Akiyama, Rumi Okuno, Takahiro Yamaguchi, Ryuji Kawahara,
et al.
mg/ml RNase A (Promega, Madison, WI, USA). Next, genomic DNA was extracted from each lysate using a
Maxwell RSC instrument
(
Promega
), according to the manufacturer’s instructions, and 250 bp paired-end libraries were then generated
(109)
Site‐Specific Mutations on KRAS , NRAS , and BRAF Corelate With the Frequency of ctDNA in Colorectal Cancer
Cancer Rep (Hoboken)
July 23, 2025
Fumihiro Yoshimura, Yoichiro Yoshida, Teppei Yamada, Keita Tanaka, Takaomi Hayashi, Hideki Shimaoka, Ryohei Sakamoto, Naoya Aisu, Gumpei Yoshimatsu, Suguru Hasegawa
from 1.0 mL plasma using the Maxwell RSC cfDNA plasma kit (Promega Corporation, Madison, WI, USA) and
Maxwell RSC Instrument
(
Promega Corporation
, Madison, USA) following the manufacturer's protocol, as described previously [19]. 2.4
(110)
Analysis of the Microbiota of Milk from Holstein-Friesian Dairy Cows Fed a Microbial Supplement
Animals (Basel)
July 18, 2025
Bronwyn E. Campbell, Mohammad Mahmudul Hassan, Timothy Olchowy, Shahab Ranjbar, Martin Soust, Orlando Ramirez-Garzon, Rafat Al Jassim, Robert J. Moore, John I. Alawneh
buffers but no sample, were loaded into the cartridges of the kit and extracted automatically on a
Maxwell® RSC instrument
(
Promega
, Madison, WI, USA). The quality and quantity of DNA were assessed using a NanoDrop™ spectrophotometer
(111)
Loss of PLA2G4E compromises synaptic structure and cognitive outcomes in mice
Life Sci Alliance
July 9, 2025
Sara Badesso, Marta Perez-Gonzalez, Sara Exposito, Maria Espelosin, Clara Cambria, Laura D'Andrea, Gabriele Imperato, Pedram Moeini, Africa Vales, Gloria Gonzalez-Aseguinolaza,
et al.
following the manufacturer’s protocol. Thanks to magnetic beads supplied in the Maxwell RSC Cartridge,
Maxwell RSC Instrument
performed RNA extraction and DNase I treatment resulting in 25-50 μl RNA-containing solution that was
(112)
Prevotella as the main driver for the association between dairy farming and human gut microbiome composition
Frontiers in Microbiomes
July 9, 2025
Tryntsje Cuperus, Jolanda Kool, David Boverhoff, Kees van der Ark, Marieke Opsteegh, Susana Fuentes
of S.T.A.R. buffer following the same
procedure
. Pooled faecal lysates were then transferred to the
Maxwell RSC Instrument
(
Promega
Benelux BV) for further
purification
steps. Eluted sample was cleaned-up using the
OneStep PCR Inhibitor Removal Kit
(113)
Discovery of glycerol phosphate and an immunogenic glycan motif in rhamnose-rich polysaccharides of Streptococcus uberis
Vet Res
July 7, 2025
Yao Shi, Göran Widmalm, Natalia Korotkova, Adrian Molenaar, Mark A. Holmes, Scott McDougall, Jetta J. E. Bijlsma, Nina M. van Sorge, Lindert Benedictus
120 rpm.
Whole-genome sequencing
and assembly Genomic DNA of S. uberis 233 was isolated using the
Maxwell® RSC Instrument
(
Promega
) after overnight growth in THY broth. DNA was quantified by
Qubit Fluorometer
(
Invitrogen
).
(114)
Efficient cell-free translation from diverse human cell types
Journal of Biological Chemistry
July 1, 2025
Jana Ziegelmüller, Nikolaos Kouvelas, Nino Schwaller, Priyanka Thambythurai, Alexander M. Hofer, Oliver Mühlemann, Evangelos D. Karousis
extraction RNA extraction for
RT-qPCR
analysis was carried out using the
Maxwell RSC Instrument
(
Promega
, Cat#
AS4500
) and the
Maxwell RSC simplyRNA Cells Kit
(
Promega
, Cat#
AS1390
), following the manufacturer’s protocol.
(115)
Comparative transcriptomics of salinomycin molecular toxicity in chicken and turkey
Sci Rep
July 1, 2025
İlksen Berfin Ekinci, Anna Sławińska, Kacper Żukowski, Małgorzata Olejnik
summarized in Fig. 1. RNA isolation The total RNA was isolated from the liver and heart samples using the
Maxwell® RSC instrument
(
Promega
, USA). The tissue size was 100 mg, and the extraction was performed with
Maxwell® RSC simplyRNA Tissue Kit
(116)
Examination of the enrichment of neuronal extracellular vesicles from cell conditioned media and human plasma using an anti-NCAM immunocapture bead approach
BMC Methods
July 1, 2025
Mary E. W. Collier, Natalie Allcock, Nicolas Sylvius, Jordan Cassidy, Flaviano Giorgini
was isolated from the EV lysates using the Maxwell RSC
miRNA
from plasma and serum kit (Promega) on a
Maxwell RSC instrument
(
Promega
) according to the manufacturer’s instructions and eluted in 40 µl of nuclease free water. RNA
(117)
Comparative Evaluation of the Serological Methods and the Molecular Genetics Techniques for the Diagnosis of Encephalitozoon cuniculi in Rabbits (Oryctolagus cuniculus)
Microorganisms
June 25, 2025
Anca-Alexandra Doboși, Anamaria Ioana Paștiu, Sanda Andrei, Dana Liana Pusta
samples, where the enzymatic digestion of the samples was performed with proteinase K at 56 °C. The
Maxwell® RSC Instrument
(
Promega
, Madison, WI, USA) for automatic extractions was required for this process and the final products
(118)
Identification of diagnostic DNA methylation markers in the blood of Japanese Alzheimer's disease patients using methylation capture sequencing
Clin Epigenetics
June 20, 2025
Risa Mitsumori, Kayoko Sawamura, Kimi Yamakoshi, Akinori Nakamura, Yutaka Arahata, Shumpei Niida, Daichi Shigemizu, Kouichi Ozaki, Nobuyoshi Shimoda
obtained from the NCGG biobank. Preparation of gDNA gDNA was extracted from peripheral blood using a
Maxwell RSC Instrument
(
Promega
, USA) with the
Maxwell RSC Buffy Coat DNA Kit
(
Promega
, USA). The quantity of gDNA was measured
(119)
Sustainable water reuse in food production: risks of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and antimicrobial resistance gene release from tertiary-treated reclaimed water
Frontiers in Microbiology
June 19, 2025
Pilar Truchado, Márcia Oliveira, Rebeca Cordero-García, Manuel Abellán Soler, Amador Rancaño, Francisca García, Avelino Álvarez-Ordóñez, Ana Allende
genomic DNA extraction. Genomic DNA extraction from wastewater concentrates was performed using the
Maxwell® RSC Instrument
(
Promega
) and the Maxwell RSC Pure Food GMO and Authentication Kit (Promega), following the Maxwell
(120)
Pollen parent affects rutin content of seeds of buckwheat (
Fagopyrum esculentum
)
Breeding Science
June 18, 2025
Shiori Otsuka, Takashi Hara, Koji Ishiguro, Kenichi Matsushima, Yasuo Yasui, Katsuhiro Matsui
with a mortar and pestle. Total RNA was extracted from the seeds with a
Maxwell RSC Plant RNA Kit
in a
Maxwell RSC Instrument
(
Promega
) according to the manufacturer’s protocol. A
Next Generation Sequencing
library was constructed
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Maxwell RSC Instrument from Promega
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