Spatial Biology Platforms

Spatial Biology Platforms The ability to observe cellular processes and phenotypes in terms of spatial and morphological context is valuable in many research areas, from basic research to clinical development in areas like immuno-oncology, neurology, cardiovascular and infectious diseases. Novel platforms allow researchers to bridge the gap between high-resolution tissue imaging and gene expression through RNA or protein detection. Methods can vary from multiplexed immunodetection of multiple protein biomarkers to whole transcriptome analysis of single tissue sections. Generally, both fresh frozen and FFPE tissue sample formats can be accommodated. Other notable features include rapid, automated imaging and integrated analysis software. Browse the spatial biology platforms below to determine which best suits the needs or capabilities of your project.

Spatial Biology Platforms

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Sponsored Products

PhenoCycler&#174;-Fusion 2.0
Akoya Biosciences, a Quanterix company
  • Description:
    Powered by high-speed imaging and proprietary barcoding technology, PhenoCycler®-Fusion 2.0 introduces multi-slide ...
  • Method:
    Barcoded-antibody cyclic staining (reveal-image-remove), ...
  • Scale:
    Whole tissue, Single cell, Subcellular
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Citations:
(12)
COMET &trade;
Bio-Techne Spatial
  • Description:
    COMET™ is a fully-automated, high-throughput, hyperplex platform, designed to obtain scalability and reproducibility ...
  • Method:
    Sequential immunofluorescence (SeqIF™); automated runs of 40...
  • Scale:
    Whole tissue, Single cell, Subcellular
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Citations:
(92)
Figures:
(11)
CosMx<sup>&#174;</sup> Spatial Molecular Imager
Bruker Spatial Biology
  • Description:
    The CosMx® Spatial Molecular Imager redefines spatial biology by enabling high-fidelity, single-cell whole-transcriptome...
  • Method:
    Multiplexed, cyclic FISH; 1000-plex for RNA and 100-plex for...
  • Scale:
    Whole tissue, single-cell, subcellular
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Citations:
(439)
Figures:
(32)
Cell DIVE Multiplexed Imager
Leica Microsystems
  • Description:
    Designed to give users the freedom and confidence to choose exactly how to design and execute their multiplexing ...
  • Method:
    Multiplex immunofluorescence imaging of 60+ biomarkers; ...
  • Scale:
    Whole tissue, single cell
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MACSima&#8482; Platform
Miltenyi Biotec
  • Description:
    The MACSima™ Platform, our revolutionary multiomics solution, streamlines your spatial biology research from end to end,...
  • Method:
    Automated cyclic staining, imaging, and erasure (MICS), ...
  • Scale:
    Whole tissue, Single cell
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Citations:
(77)
Figures:
(2)
Orion™ Platform
RareCyte
  • Description:
    Orion™ Platform is the first and only multiplex immunofluorescence (mIF) platform to enable 20-channel single-round ...
  • Method:
    Single-round 20-channel mIF, multispectral fluorescence with...
  • Scale:
    Whole tissue, Single cell
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Citations:
(36)
Figures:
(4)
Pyxa® 3D Automated Confocal Spatial Platform
Stellaromics
  • Description:
    Pyxa is the first platform for true spatial multi-omic analysis of thick tissue sections in 3D. Pyxa is an automated ...
  • Method:
    STARmap™ in situ RNA sequencing, hydrogel-tissue chemistry, ...
  • Scale:
    Whole tissue, single cell, sub-cellular
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Invitrogen™ EVOS™ S1000 Spatial Imaging System
Thermo Fisher Scientific
  • Description:
    The Invitrogen™ EVOS™ S1000 Spatial Imaging can complete the imaging process quickly while generating a fully stitched, ...
  • Method:
    Spectral fluorescence with unmixing, transmitted, phase, and...
  • Scale:
    Whole tissue, Single cell
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TissueFAXS Spectra Multispectral Imaging System
TissueGnostics
  • Description:
    Use TissueFAXS Spectra for whole-slide multispectral imaging as well as high-end image analysis. This system allows the ...
  • Method:
    Multispectral imaging with LCTF and built-in unmixing, ...
  • Scale:
    Whole tissue, Single cell
Read More
Citations:
(66)
Xenium Analyzer High-throughput in situ Analyzer
10x Genomics
  • Description:
    Xenium In Situ is the next-level in situ solution for subcellular profiling of 100s of RNA targets, in fresh frozen or ...
  • Method:
    In situ probe hybridization, RCA, fluorescent probe ...
  • Scale:
    Whole tissue, single-cell, subcellular
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PhenoCycler&reg; instrument
Akoya Biosciences, a Quanterix company
  • Description:
    The PhenoCycler® instrument (formerly CODEX®) is a cutting-edge fluidics control unit that integrates with the ...
  • Method:
    Automated cycling and labeling of analytes for whole-slide ...
  • Scale:
    Whole tissue, single cell
Read More
Citations:
(135)
Figures:
(6)
PhenoCycler&reg;-Fusion System
Akoya Biosciences, a Quanterix company
  • Description:
    The PhenoCycler®-Fusion system is the fastest spatial biology solution that enables ultrahigh-plex spatial ...
  • Method:
    Automated cycling and iterative imaging of 100+ biomarkers ...
  • Scale:
    Whole tissue, single cell
Read More
Citations:
(93)
Figures:
(4)
PhenoImager&reg; HT instrument
Akoya Biosciences, a Quanterix company
  • Description:
    Providing unparalleled speed, performance, and throughput, the PhenoImager® HT instrument integrates the power of ...
  • Method:
    Multispectral imaging with onboard spectral unmixing (Opal ...
  • Scale:
    Whole tissue, Single cell, Subcellular
Read More
Citations:
(207)
Figures:
(8)
CellScape&#8482; XR Platform
Bruker Spatial Biology
  • Description:
    High fidelity, flexible subcellular proteomics for rapid and quantitative spatial phenotyping

    The CellScape™ XR...
  • Method:
    Highly multiplexed immunofluorescence of multiple protein ...
  • Scale:
    Whole tissue, single-cell, subcellular
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GeoMx<sup>&#174;</sup> Digital Spatial Profiler
Bruker Spatial Biology
  • Description:
    Experience discovery-scale spatial multiomics with the GeoMx Digital Spatial Profiler (DSP). GeoMx DSP enables high-plex...
  • Method:
    Barcoded antibodies or RNA probes, UV-cleaved barcodes from ...
  • Scale:
    Whole tissue
Read More
iMScope QT Imaging Mass Microscope
Shimadzu
  • Description:
    The iMScope QT Imaging Mass Microscope is a combination of an optical microscope and an AP-MALDI ion source enabling ...
  • Method:
    Inquire
Citations:
(31)
Hyperion+&#8482; Imaging System
Standard BioTools Inc.
  • Description:
    The Hyperion+™ Imaging System uses Imaging Mass Cytometry™ (IMC™) to visualize the complex spatial biology of the ...
  • Method:
    Imaging mass cytometry (CyTOF) using mass-tagged antibodies;...
  • Scale:
    Whole tissue, single cell
Read More
Citations:
(229)
Figures:
(7)
Atera
10x Genomics
  • Description:
    Atera offers a 625 mm² imageable area per slide, or 2,500 mm² of total tissue per run when all four slides are used, and...
  • Method:
    In situ probe hybridization, RCA, cyclic multichannel ...
  • Scale:
    Whole tissue, Single cell, Subcellular
Read More
Inquire
Visium Spatial Gene Expression
10x Genomics
  • Description:
    Visium Spatial Gene Expression is a next-generation molecular profiling solution for classifying tissue based on total ...
  • Method:
    Slide-based mRNA capture and sequencing to analyze the whole...
  • Scale:
    Whole tissue, single cell
Read More
RNAscope&#8482; In Situ Hybridization
Advanced Cell Diagnostics
  • Description:
    RNAscope Technology is a novel in situ hybridization (ISH) assay for detection of target RNA within intact cells. The ...
  • Method:
    In situ hybridization (ISH) assay - single to 12-plex
  • Scale:
    Whole tissue, single cell
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Autiva Spatial Phenotyper
Leica Microsystems
  • Description:
    The Autiva Spatial Phenotyper is an automated, open spatial biology platform that integrates cyclic immunofluorescence ...
  • Method:
    Automated cyclic mIF, microfluidic stain-image-destain ...
  • Scale:
    Whole tissue, Single cell
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G4X™ Spatial Sequencer
Singular Genomics
  • Description:
    High-throughput in-situ spatial sequencing for transcriptomic and proteomic analysis from FFPE samples at subcellular ...
  • Method:
    In situ SBS with padlock-probe detection of RNA and protein,...
  • Scale:
    Whole tissue, Single cell, Subcellular
Read More
Citations:
(4)
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Select up to 5 products from above to compare or request more information.

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Bio-Techne Spatial
COMET
Extended Data  3
11 Figures from 92 Publications
Bruker Spatial Biology
CosMx
3
32 Figures from 439 Publications
Miltenyi Biotec
MACSima
1
2 Figures from 77 Publications
RareCyte
Orion
Extended Data  4
4 Figures from 36 Publications
Akoya Biosciences, a Quanterix company
PhenoCycler
6
6 Figures from 135 Publications
Akoya Biosciences, a Quanterix company
PhenoCycler-Fusion
1
4 Figures from 93 Publications
Akoya Biosciences, a Quanterix company
PhenoImager HT
2
8 Figures from 207 Publications
Standard BioTools Inc.
Hyperion+
7
7 Figures from 229 Publications
Showing 8 of 8 products
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  • 10x Genomics
  • Advanced Cell Diagnostics
  • Akoya Biosciences, a Quanterix company
  • Bio-Techne Spatial
  • Bruker Spatial Biology
  • Leica Microsystems
  • Miltenyi Biotec
  • RareCyte
  • Shimadzu
  • Singular Genomics
  • Standard BioTools Inc.
  • Stellaromics
  • Thermo Fisher Scientific
  • TissueGnostics