Hyperion+™ Imaging System from Standard BioTools Inc.

Product Specs
ItemHyperion+™ Imaging System
CompanyStandard BioTools Inc.
Price Get Pricing Get Quote for this Product
Catalog NumberHyperion+
MethodImaging mass cytometry (CyTOF) using mass-tagged antibodies; 40+ protein marker detection
ScaleWhole tissue, single cell
QuantityEA

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Standard BioTools Inc.

2 Tower Place, Suite 2000

South San Francisco, California 94080

United States

Phone: 650 266 6000 | Main
866 359 4354 | Toll-free

Company Profile

Website: http://standardbio.com

(1) Peritoneal macrophages regulate distal wound healing via endocrine release of plasma fibronectinJournal of Clinical InvestigationMay 1, 2026Lilian Salm, Simone N. Zwicky, Daniel Spari, Tural Yarahmadov, Marie Siwicki, Fernanda Vargas E Silva Castanheira, Jonas Zbinden, Deborah Stroka, Joel Zindel, Antoine Dufour, et al.airflow hood. Sample acquisition on imaging mass cytometer. Images were acquired on a Standard BioTools Hyperion Imaging System with the CyTOF 7 software operated by the IMC Platform at the University of Bern and Inselspital. Quality

(2) Single-Cell Profiling Reveals a Treg-Rich, NK Cell-Depleted Immune Microenvironment in Triple-Negative Breast Cancer with High-Glucocorticoid Receptor ExpressionBreast Cancer (Dove Med Press)April 14, 2026Joshua Behar, Christine Shiang, Deniz Nesli Dolcen, Lynda B Bennett, Andrew W DeVilbiss, Margarite D Matossian, Isaac S Chan, Rita Nanda, Suzanne D Conzen, John T Lafinmaintained in sealed containers to avoid contaminating metals. These slides were subsequently analyzed by Hyperion IMC spatial proteomics.13–16 Throughout the IMC staining process, all reagents were prepared in Maxpar

(3) Single-cell spatial atlas of the aging human breastNature AgingMarch 31, 2026Pulkit Gupta, Eric Lee, Neus Masqué Soler, Ellen Schrader, Xiao Qian Wang, Shimrit Mayer, Cristina Flores, Sean Beatty, Andrew Roth, Samuel Aparicio, et al.including conjugation of platinum56 and bismuth57,58 isotopes. Finally, stained tissues were ablated with a Hyperion+ Imaging Mass Cytometer (Standard BioTools), and intensities were quantified using time-of-flight mass

(4) Inhaled Angiopoietin‐Like 4 Antisense Oligonucleotide Therapy for Lung Injury and FibrosisAdvanced ScienceMarch 23, 2026Haiyang Fan, Yuanyang Tan, Junhang Zhang, Xiaoya Liu, Jing Qu, Damien Chua, Hong Sheng Cheng, Joseph Han Sol Kim, Yu Xuan Liu, Changfei Qin, et al.ddH2O, and air‐dried for over 20 min. Imaging was performed using an imaging mass cytometer (Fluidigm Hyperion, Standard BioTools Inc., MA, USA). Quantitative fluorescence analysis was performed by ImageJ (version:

(5) Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS-chemokine-myeloid axisSci AdvMarch 13, 2026Bruno Beernaert, Rose L. Jady-Clark, Parin Shah, Erik Ramon-Gil, Nora M. Lawson, Zack D. Brodtman, Somnath Tagore, Frederik Stihler, Alfie S. Carter, Shannique Clarke, et al.slides were washed and left to dry, ready for laser ablation. Image acquisition was performed using the Hyperion Fluidigm (Standard BioTools). Cell segmentation on resulting images was performed using the OPTIMAL

(6) Deep Learning Enabled 3D Multi-Omic Analysis Reveals Molecular Signatures of Heterogeneous Response to Chemotherapy in Pancreatic CancerbioRxivMarch 5, 2026André Forjaz, Hengameh Mojdeganlou, Alens Valentin, Meredith Wetzel, Dmitrijs Lvovs, Atul Deshpande, Sarah M. Shin, Sujan Piya, Kimal I Rajapakshe, Paola A Guerrero, et al.minutes at RT. Finally, slides were washed in Maxpar water and then air dried before being loaded in the Hyperion Imaging Plus System (Standard BioTools; RRID: SCR_023195) for image acquisition at the Johns Hopkins

(7) Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen ExposureAdvanced ScienceMarch 1, 2026Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, et al.at 4°C before and after data acquisition. Tissue ablation was performed using the Standard BioTools Hyperion imaging mass cytometer in the MDACC North Campus Flow Cytometry and Cellular Imaging Core Facility. 4.5

(8) Computational Modeling of Cellular Influence Delineates Functionally Relevant and Distinct Cellular Neighborhoods in Primary and Metastatic Pancreatic Ductal AdenocarcinomaCancer Immunology ResearchFebruary 26, 2026Yeonju Cho, Jae W. Lee, Sarah M. Shin, Alexei G. Hernandez, Xuan Yuan, Jowaly Schneider, Jody E. Hooper, Laura D. Wood, Elizabeth M. Jaffee, Atul Deshpande, et al.used for IMC is provided in Supplementary Table S2. After staining, images were acquired using the Hyperion Imaging System (Standard BioTools) at the Johns Hopkins Mass Cytometry Facility. IMC provides high-dimensional spatial

(9) Myeloid landscape profiling identifies DLBCL-specific suppressive macrophages colocalized with blood endothelial cells∗Blood AdvancesFebruary 24, 2026Juliette Ferrant, Simon Le Gallou, Francine Padonou, Charlotte Dubec-Fleury, Simon Leonard, Ilenia Papa, Charles Brottier, Céline Pangault, Anne Barthel, Vincent Launay, et al.201192A, Standard BioTools) and drying. Region of interest (ROI) (2 or 3 per sample) were acquired using Hyperion IMC (Standard BioTools) after tuning the instrument according to the manufacturer’s instructions. Cell

(10) iCLAP: an innovative method for integrable co-detection of low-abundance antigens with high-plex immunostainingNature CommunicationsFebruary 24, 2026Fan Wu, Shuyuan Zheng, Yani Chen, Peijia Ye, Moo Joong Kim, Seojin Lee, Geroge Kuo, Shriya Pillan, Ruihan Yuan, Kyu Sang Han, et al.3 min at room temperature. Following Maxpar water washes, slides were air-dried and placed into the Hyperion Imaging Plus System (Standard Biotools) for image acquisition at the Johns Hopkins Mass Cytometry Facility. iCLAP

(11) A universal platform for simultaneous TCRα/β removal enables safer and more potent TCR therapies and autoimmune modelingbioRxivFebruary 23, 2026Giorgia Zanetti, Mateusz Legut, Austin Chen, Farshid Fathi, Nathan Suek, Nato Teteloshvili, Hao Wei Li, Xiaolan Ding, Daniel Traum, Klaus H. Kaestner, et al.processed and stained with a 37-antibody panel as described 71. Acquisition was performed using the Hyperion Imaging System (Standard BioTools) at 200 Hz, and images were analyzed in HALO v4.1. Further details on imaging mass cytometry

(12) Spatial single-cell analysis reveals tumor microenvironment signatures predictive of oral cavity cancer outcomeCell Reports MedicineFebruary 17, 2026Joni Näsiaho, Linda Nissi, Sami Ventelä, Heikki Irjala, Marko Salmitwice in PBS and stored dry at RT for IMC. We carried out mass cytometric analyses of the samples with Hyperion imaging system instrument and CyTOF software using standard protocols. We identified the ROIs from optical panorama

(13) Glioinflammation: disease-associated microglia and astrocytes in psychiatric disorders, neurodegeneration, and senescenceFrontiers in Cellular NeuroscienceFebruary 17, 2026Kumiko Uemura, Shunya Hiro, Suthinee Attachaipanich, Ruixue Du, Nur Intan Saidaah Mohamed Yusof, Miyu Kinoshita, Momoka Hikosaka, Gen Ohtsukihigh-dimensional mapping of protein expression across tissue sections. Notable technologies include Hyperion (Standard BioTools), CosMx and GeoMx (NanoString), CellSpace (Bruker), PhenoCycler®-Fusion (Akoya Biosciences),

(14) Imaging mass cytometry unveils functional and spatial remodeling of peri-lesional cells in jaw osteonecrosisCommunications BiologyFebruary 16, 2026Jiazheng Cai, Ying Xue, Stian Tornaas, Harsh Nitin Dongre, Athanasia Bletsa, Sigbjørn Løes, Peter Schleier, Evelyn Neppelberg, Arild Kvalheim, Ellen Berggreen, et al.single-cell segmentation. IMC data acquisition and preprocessing Raw imaging data were acquired using the Hyperion Imaging System (Standard BioTools Inc., South San Francisco, CA, USA) in combination with CyTOF software v7.0, following

(15) IL-36γ armored CAR T cells reprogram neutrophils to induce endogenous antitumor immunityCancer CellFebruary 9, 2026Yihan Zuo, David J. Vohwinkel, Bowen Dong, James R. McDowell, Brandon V. Guzman, Tharuna Sri Manickavel Manickavel Pandian, Saborni Chattopadhyay, A.J.R. McGray, Scott H. Olejniczak, Joyce Ohm, et al.chamber, washed with distilled water, and air dried prior to acquisition. Images were acquired using a Hyperion Imaging System (Standard Biotools). Regions of interest (1 mm²) were selected based on hematoxylin and eosin-stained

(16) AADAT-Driven Metabolic Control of Malate and CoQ 10 Shapes Immune Evasion in Triple-Negative Breast CancerbioRxivJanuary 31, 2026Megha Chatterjee, Franklin Gu, Susmita Samanta, Uttam Rasaily, Sai Manohar Thota, Dana Varghese, Yunping Qiu, Lynette Ewura Esi Fordwuo, Hugo Villanueva, Mary Kathryn McKenna, et al.washed, air-dried, and stored for ablation. Data acquisition was performed through ablation using the Hyperion system (Standard BioTools). The data from Roswell Park TNBC cohort is detailed in our previous publication59. Image

(17) Cytometric Atlas of Combination Immunotherapy in Pancreatic Cancer: Blood-Based Signatures Reveal Vaccine and Checkpoint Inhibitor ResponsesCancer Immunology ResearchJanuary 29, 2026Dimitrios N. Sidiropoulos, Zhehao Zhang, Jennifer N. Durham, Soren Charmsaz, Nicole E. Gross, Jae W. Lee, Yanyi Sun, Susheel Perikala, Joseph A. Tandurella, Dmitrijs Lvovs, et al.temperature. After another wash in Maxpar water for 5 minutes, slides were air-dried and loaded into the Hyperion Imaging Plus System (Standard BioTools) at the Johns Hopkins Mass Cytometry Facility. Selected representative

(18) A Randomized Phase II Study: CRS207/GVAX plus Anti–PD-1 and Anti-CTLA4 Recruits Mesothelin- and mKRAS-Specific T Cells into PDACCancer Immunology ResearchJanuary 28, 2026Katherine M. Bever, Amanda L. Huff, Ludmila Danilova, Meredith Wetzel, Joseph A. Tandurella, Jennifer N. Durham, Tingchang Wang, Jae W. Lee, Erin M. Coyne, Janelle M. Montagne, et al.and used as a tissue counterstain. The slides were air dried and ablated for data acquisition using Hyperion PLUS™ at Johns Hopkins Mass Cytometry Facility. Images were segmented into single-cell dataset using

(19) Multimodal single-cell and spatial profiling reveals altered T cell-mediated immunity and B-cell follicular architecture in non-metastatic lymph nodes of patients with aggressive non-small cell lung cancermedRxivJanuary 23, 2026Zhan Hao Xi, Yusuke Koga, Shannon McDermott, Erin E. Kane, Roxanna Pfefferkorn, Ehab Billatos, Paul R. Hosking, Jennifer E. Beane, Eric J. Burks, Sarah A. Mazzilli, et al.were washed with ddH2O and air-dried. Ablation was performed at 1 μm resolution and 200 Hz using the Hyperion Imaging System (Standard BioTools, South San Francisco, CA, USA). IMC image processing and segmentation. Raw pixel

(20) Multi-view deep learning of highly multiplexed imaging data improves association of cell states with clinical outcomesBioinformatics AdvancesJanuary 14, 2026Shanza Ayub, Jennifer L Gorman, Edward L Y Chen, Hartland W Jackson, Alina Selega, Kieran R Campbellsupplementary data at Bioinformatics Advances online. Acquisition: IMC acquisition was performed on a Hyperion Imaging System with 400 Hz ablation after successful instrument QC (Standard BioTools). Multiple ROIs were acquired

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