Hyperion+™ Imaging System from Standard BioTools Inc.

Product Specs
ItemHyperion+™ Imaging System
CompanyStandard BioTools Inc.
Price Get Pricing Get Quote for this Product
Catalog NumberHyperion+
MethodImaging mass cytometry (CyTOF) using mass-tagged antibodies; 40+ protein marker detection
ScaleWhole tissue, single cell
QuantityEA

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Standard BioTools Inc.

2 Tower Place, Suite 2000

South San Francisco, California 94080

United States

Phone: 650 266 6000 | Main
866 359 4354 | Toll-free

Company Profile

Website: http://standardbio.com

(1) Dissecting Immune Determinants in Lesional Skin of Cutaneous T-Cell Lymphoma During Mogamulizumab TherapyCancers (Basel)July 21, 2026Xiao Ni, Wei Han, Niharika Kunta, Meghali Goswami, Jared K. Burks, Ye Zheng, Youn H. Kim, Madeleine Duvicto IMC image acquisition. 2.5. IMC Image Acquisition Imaging mass cytometry was performed on the Hyperion™ XTi Imaging System (Standard BioTools, Boston, MA, USA) at a laser repetition rate of 200 Hz by the

(2) Spatial Omics Technologies in Glioblastoma Research: Principles, Applications, and Best PracticesGenes (Basel)July 18, 2026Maxime Vanmechelen, Chiara Caprioli, Paul M. Clement, Ann Hoeben, Frederik De Smetprotein,Targeted,Single-cell,100+ proteins,FFPE & fresh frozen,Very high protein plexity,Long imaging runs Hyperion MIBI-TOF (Standard Biotools),Metal-tagged antibodies,Protein,Targeted,~200 nm–10 µm,40–50 proteins,FFPE

(3) Hypoxia shapes both therapeutic response and resistance in metastatic clear cell renal cell carcinomaCancer CellJuly 13, 2026Lynda Vuong, Andrew E. Cornish, Jennifer Pfeil, Yash Khandwala, Hui Jiang, Doris X.T. Zheng, Eduardo A. Mascareno, Nicole Rittenhouse, Phillip M. Rappold, Josef Leibold, et al.control adult tonsil and representative ccRCC tissues samples. Image acquisition was conducted using the Hyperion XT and XTi Imaging Systems (Standard BioTools) at 1 μm resolution and 800 Hz laser ablation. Acquisition

(4) Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matterNat AgingJuly 13, 2026Chase M. Carver, Paul T. Gomez, Sonia L. Rodriguez, James T. Redden, Amanda S. Latham, Yooree Ha, Jennifer M. Kachergus, Yi Liu, Ji Shi, Tommy Tran, et al.each metal-conjugated antibody, distinguished by time-of-flight mass cytometer, were acquired by the Hyperion Imaging System (Standard BioTools), reconstructed into an image. Representative images were converted to OME.TIFF files

(5) A pilot imaging mass cytometry study of cutaneous nerve-immune cell interactions in post-herpetic neuralgiaFront ImmunolJuly 8, 2026Siddhesh N. Telang, Jackson F. Karrasch, Philip M. Finch, Stefanie S. Kogias, Thomas R. O'Neil, Anthony L. Cunningham, Andrew N. Harman, Peter D. Drummond, Paul J. AustinIntercalator-Ir (DVS Sciences, 201192A), rinsed, and air-dried. All immunolabelled sections were imaged using a Hyperion™ Imaging System (Standard BioTools). Regions of interest spanning the dermal-epidermal border were selected following

(6) Cellular interaction of mycosis fungoides tumor cells changes from cytotoxic CD8+ T cells in plaques to B cells in tumorsFront ImmunolJuly 2, 2026Veerle A. Merkus, Marieke E. IJsselsteijn, Marie S. N. Chevalier, Sanne de Haan, Vincent van Unen, Cornelis P. Tensen, Abdoel El Ghalbzouri, Anne M. R. Schrader, Ferenc A. Scheeren, Noel F. C. C. de Miranda, et al.demonstrated strong IHC performance were subsequently conjugated to a heavy metal and evaluated using the Hyperion Imaging System (Standard BioTools, San Francisco, CA, USA). The antibodies were conjugated in-house with heavy metal

(7) TERT drives liver tumorigenesis beyond telomere elongationLife Sci AllianceJuly 2, 2026Laura Braud, Julien Vernerey, Arnaud Guille, Pierre Cordier, Clémence Ginet, Tom Egger, Manuel Bernabe, Dmitri Churikov, Quentin Da Costa, Aïda Meghraoui, et al.signature was from Mitsuishi et al (2012a). Imaging Mass Cytometry (IMC) IMC was performed using the Hyperion Imaging System (Standard BioTools), a multiplexed spatial proteomics platform that enables simultaneous detection of

(8) Multimodal characterisation of spontaneous Merkel cell carcinoma in the endangered Caucasian squirrel (Sciurus anomalus pallescens): integrating spatial transcriptomics, imaging mass cytometry and metagenomic sequencingJ Vet ResJune 30, 2026Peyman Mohammadzadeh, Amin Pilvaieh, Arshia Dousti, Mohammad Reza Salim Bahrami, Farshad Ziaeeenrichment – were performed in Seurat v. 4.3 (14). Imaging mass cytometry This was performed on a Fluidigm Hyperion Imaging System (Standard BioTools, San Francisco, CA, USA). Formalin-fixed, paraffin-embedded tissue sections 4 μm

(9) Spatial immune atlas of breast cancer brain metastasis reveals CD163+ macrophage reprogramming associated with immune escapeJ Immunother CancerJune 24, 2026Jiale Zhu, Junjie Ye, Yulin Ma, Zhirong Lin, Yupeng Wen, Jianpeng Sheng, Mei Yang4°C with the antibody cocktail, slides were counterstained with iridium intercalator and imaged on a Hyperion Imaging System (Standard BioTools) at 1 µm resolution with identical acquisition parameters for all specimens.42 Image

(10) Density-Adjusted Analysis of Cell Interactions to Decipher Tissue Landscape ChangesiScienceJune 19, 2026Misha Siddiqui, Azam Hamidinekoo, Jennifer Y. Tan, Renata Leke, Bader Zarrouki, Nick Trahearn, Yeman Brhane Hagos, Chirine Sakr, Andrea Lampis, Christopher Bagnall, et al.were then fixed and stained with the panel of antibodies shown in key resources table for IMC with the Hyperion system (Standard Biotools, San Francisco, CA, USA) according to the manufacturer’s guidelines. Images

(11) Mechanisms of increased Alzheimer's disease pathology with R47H and R62H TREM2 variantsActa NeuropatholJune 15, 2026Nurun N. Fancy, Nanet Willumsen, Vicky M. N. Chau, Samuel L. Boulger, Harry J. Whitwell, Wenhao Wang, Baptiste Avot, Michael Thomas, Jonathan Talbot-Martin, Stergios Tsartsalis, et al.conjugation was performed using the Maxpar X8 protocol (Standard BioTools). IMC was performed using a Hyperion Imaging Systems First Generation (Standard BioTools) coupled to a CyTOF First Generation mass cytometer

(12) Spatiotemporal organisation of residual disease in mouse and human BRCA1-deficient mammary tumours and breast cancerNature CommunicationsJune 11, 2026Demeter Túrós, Morgane Decollogny, Anna Moyseos, Astrid Chanfon, Myriam Siffert, Joanne Bousmar, Lou Romanens, Jean-Christophe Tille, Olivier Tredan, Intidhar Labidi-Galy, et al.quickly rinsed in distilled water and air-dried prior to acquisition. IMC data were acquired using the Hyperion™ Tissue Imager (Standard BioTools). Tissue was ablated using a 1 μm-diameter UV laser operating at 200

(13) Modeling immune responses to autologous and allogeneic human stem cell–derived islet grafts in vivoJCI InsightJune 8, 2026Camillo Bechi Genzano, Giorgia Zanetti, Qian Du, Daniel Traum, Deeksha Lahori, Grant M. Downes, Sakshi A. Bhatele, Xiaolan Ding, Kyle D. Apley, Rebuma Firdessa Fite, et al.twice in ultrapure 18.2 MΩ water, before being air dried and acquired on the IMC (Standard BioTools, Hyperion Imaging System) according to Standard BioTools’ standard operating procedures, with a 200 Hz laser frequency and a

(14) Mapping Immunity With Cutting‐Edge Spatial Biology and Tissue Cytometry InnovationsMedComm (2020)June 1, 2026Lilibeth Cárdenas‐Piedra, Selwin G. Samuel, Felicitas Mungenast, Dinesh Yasothkumar, Rupert C. Ecker, Jyotsna Batraauto‐configuration after dye selection Up to 9‐plex in a single round,Manual sample preprocessing and staining,[44] Hyperion XTi imaging System/ Standard Biotools,RNA: FISH/ RNAscope (RNAscope HiPlex V2) Protein: mass‐tagged

(15) ICAM1high Neutrophils Sculpt Tumor Evolution and Metastasis through Symbiotic Adhesion and Reverse MigrationCancer ResMay 28, 2026Ling Wu, Zhan Xu, Jun Wang, Fengshuo Liu, Yunfeng Ding, Yang Gao, Siyue Wang, Jun Liu, Hilda L. Chan, Weiguo Wu, et al.antibodies used were listed in Supplementary Table 2. Imaging mass cytometry data was acquired using Hyperion Tissue Imaging System (Standard BioTools™) at the Cytometry and Cell Sorting Core of Baylor College

(16) MIAAIM: Multi-omics image integration with dimensional reduction for tissue state mappingPLOS Computational BiologyMay 26, 2026Joshua M. Hess, Richard K. Dzeng, Iulian Ilieş, Denis Schapiro, John J. Iskra, Divya Mirgh, John Nam, Erin H. Seeley, David E. Verrill, Walid M. Abdelmoula, et al.were set for each of the 30 individual cores imaged from the TMA and acquired on a Standard Biotools Hyperion system at resolution of 1μm2. Generation of prostate TMA mass spectrometry imaging data. For MSI imaging

(17) Deep phenotyping of skin tissue remodeling in patients with systemic sclerosis treated with CD19-CAR T cellsNat CommunMay 23, 2026Aleix Rius Rigau, Meilin Xu, Ziyuan Liu, Sara Chenguiti Fakhouri, Janina Auth, Panagiotis Garantziotis, Andrea Zoli, Manoj Kumar Selvaraju, Maria Gabriella Raimondo, Carlo Tur, et al.by time-of-flight (CyTOF) (Helios, Standard Biotools, South San Francisco, Ca, USA) coupled to the Hyperion Imaging System (Standard Biotools, South San Francisco, Ca, USA). Tissue ablation was performed at a laser frequency

(18) High-dimensional Spatial Immune Profiling Highlights Microglia-Like Cells in Human Dorsal Root GangliaEur J ImmunolMay 19, 2026Marius Schwabenland, Busranur Oeztuerk, Thomas Blank, Juergen Beck, Bertram Bengsch, Marco PrinzIntercalator (Standard BioTools, cat. #201192A) for 30 min. IMC data acquisition was carried out using the Hyperion Imaging System (Fluidigm/Standard BioTools). Image segmentation was conducted using the IMCSegmentationPipeline as

(19) Quantitative 3D histology reveals localized immune remodeling during early pancreatic cancer progressionCell Press BlueMay 18, 2026Ashley L. Kiemen, Valentina Matos, Cristina Almagro-Pérez, André Forjaz, Alicia M. Braxton Braxton Hickman, Lucie Dequiedt, Jeeun Parksong, Courtney D. Cannon, Xuan Yuan, Sarah M. Shin, et al.in Maxpar PBS and stained. A final wash was performed in Maxpar Water. Images were acquired with a Hyperion Imaging System (Standard BioTools) at the Johns Hopkins Mass Cytometry Facility. Following acquisition, stacks of multi-layered

(20) Microglial-Derived IGF-1 Serves as a Regulator for Neuroimmune Homeostasis During Viral-Induced DemyelinationVirusesMay 9, 2026Vanessa M. Scarfone, Collin Pachow, Pauline U. Nguyen, Anita Lakatos, Jamie-Jean De La Torre, Alisa Xie, Kellie Fernandez, Charlene Collado, Kaitlin Murray, Roberto Tinoco, et al.alongside mouse-level comparisons and effect sizes. IMC image processing. IMC data were acquired on a Hyperion imaging system (Standard BioTools) using a 27-marker panel across 39 tissue images from 12 animals (6 Cre-CTRL, 6 MG-Igf1KO)

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