Hyperion+™ Imaging System from Standard BioTools Inc.

Product Specs
ItemHyperion+™ Imaging System
CompanyStandard BioTools Inc.
Price Get Pricing Get Quote for this Product
Catalog NumberHyperion+
MethodImaging mass cytometry (CyTOF) using mass-tagged antibodies; 40+ protein marker detection
ScaleWhole tissue, single cell
QuantityEA

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Standard BioTools Inc.

2 Tower Place, Suite 2000

South San Francisco, California 94080

United States

Phone: 650 266 6000 | Main
866 359 4354 | Toll-free

Company Profile

Website: http://standardbio.com

(1) Density-Adjusted Analysis of Cell Interactions to Decipher Tissue Landscape ChangesiScienceJune 19, 2026Misha Siddiqui, Azam Hamidinekoo, Jennifer Y. Tan, Renata Leke, Bader Zarrouki, Nick Trahearn, Yeman Brhane Hagos, Chirine Sakr, Andrea Lampis, Christopher Bagnall, et al.were then fixed and stained with the panel of antibodies shown in key resources table for IMC with the Hyperion system (Standard Biotools, San Francisco, CA, USA) according to the manufacturer’s guidelines. Images

(2) Deep phenotyping of skin tissue remodeling in patients with systemic sclerosis treated with CD19-CAR T cellsNat CommunMay 23, 2026Aleix Rius Rigau, Meilin Xu, Ziyuan Liu, Sara Chenguiti Fakhouri, Janina Auth, Panagiotis Garantziotis, Andrea Zoli, Manoj Kumar Selvaraju, Maria Gabriella Raimondo, Carlo Tur, et al.by time-of-flight (CyTOF) (Helios, Standard Biotools, South San Francisco, Ca, USA) coupled to the Hyperion Imaging System (Standard Biotools, South San Francisco, Ca, USA). Tissue ablation was performed at a laser frequency

(3) High-dimensional Spatial Immune Profiling Highlights Microglia-Like Cells in Human Dorsal Root GangliaEur J ImmunolMay 19, 2026Marius Schwabenland, Busranur Oeztuerk, Thomas Blank, Juergen Beck, Bertram Bengsch, Marco PrinzIntercalator (Standard BioTools, cat. #201192A) for 30 min. IMC data acquisition was carried out using the Hyperion Imaging System (Fluidigm/Standard BioTools). Image segmentation was conducted using the IMCSegmentationPipeline as

(4) Microglial-Derived IGF-1 Serves as a Regulator for Neuroimmune Homeostasis During Viral-Induced DemyelinationVirusesMay 9, 2026Vanessa M. Scarfone, Collin Pachow, Pauline U. Nguyen, Anita Lakatos, Jamie-Jean De La Torre, Alisa Xie, Kellie Fernandez, Charlene Collado, Kaitlin Murray, Roberto Tinoco, et al.alongside mouse-level comparisons and effect sizes. IMC image processing. IMC data were acquired on a Hyperion imaging system (Standard BioTools) using a 27-marker panel across 39 tissue images from 12 animals (6 Cre-CTRL, 6 MG-Igf1KO)

(5) Tumor-Immune-On-Chip to Evaluate Pathophysiological Feature of T Lymphocytes Expanded from Patient Tumors and Lymph Node TissuesCancer MedMay 3, 2026Gyu-Bon Cho, Hyun-Joo Lee, You Jeong Heo, Jihoon Ko, Won-Suk Lee, Sujin Hyungdiluted in PBS to detect nuclei. Stained tissues were analyzed using the Imaging Mass Cytometry (IMC), Hyperion (Standard BioTools Inc.) according to the manufacturer's instructions. Regions of interest in whole

(6) Peritoneal macrophages regulate distal wound healing via endocrine release of plasma fibronectinJournal of Clinical InvestigationMay 1, 2026Lilian Salm, Simone N. Zwicky, Daniel Spari, Tural Yarahmadov, Marie Siwicki, Fernanda Vargas E Silva Castanheira, Jonas Zbinden, Deborah Stroka, Joel Zindel, Antoine Dufour, et al.airflow hood. Sample acquisition on imaging mass cytometer. Images were acquired on a Standard BioTools Hyperion Imaging System with the CyTOF 7 software operated by the IMC Platform at the University of Bern and Inselspital. Quality

(7) Single-Cell Profiling Reveals a Treg-Rich, NK Cell-Depleted Immune Microenvironment in Triple-Negative Breast Cancer with High-Glucocorticoid Receptor ExpressionBreast Cancer (Dove Med Press)April 14, 2026Joshua Behar, Christine Shiang, Deniz Nesli Dolcen, Lynda B Bennett, Andrew W DeVilbiss, Margarite D Matossian, Isaac S Chan, Rita Nanda, Suzanne D Conzen, John T Lafinmaintained in sealed containers to avoid contaminating metals. These slides were subsequently analyzed by Hyperion IMC spatial proteomics.13–16 Throughout the IMC staining process, all reagents were prepared in Maxpar

(8) Single-Cell Profiling Reveals a Treg-Rich, NK Cell-Depleted Immune Microenvironment in Triple-Negative Breast Cancer with High-Glucocorticoid Receptor ExpressionBreast Cancer (Dove Med Press)April 14, 2026Joshua Behar, Christine Shiang, Deniz Nesli Dolcen, Lynda B Bennett, Andrew W DeVilbiss, Margarite D Matossian, Isaac S Chan, Rita Nanda, Suzanne D Conzen, John T Lafinmaintained in sealed containers to avoid contaminating metals. These slides were subsequently analyzed by Hyperion IMC spatial proteomics.13–16 Throughout the IMC staining process, all reagents were prepared in Maxpar

(9) Computational modeling of cellular influence delineates functionally relevant and distinct cellular neighborhoods in primary and metastatic pancreatic ductal adenocarcinomaCancer Immunol ResApril 2, 2026Yeonju Cho, Jae W. Lee, Sarah M. Shin, Alexei G. Hernandez, Xuan Yuan, Jowaly Schneider, Jody E. Hooper, Laura D. Wood, Elizabeth M. Jaffee, Atul Deshpande, et al.used for IMC is provided in Supplementary Table S2. After staining, images were acquired using the Hyperion Imaging System (Standard BioTools) at the Johns Hopkins Mass Cytometry Facility. IMC provides high-dimensional spatial

(10) MIMIC: a flexible pipeline to register and summarize IMC-MSI experimentsCommunications BiologyApril 1, 2026Reto Gerber, Jake Griner, Silvia Guglietta, Carsten Krieg, Mark D. Robinsonh. Approximately 1000 μm × 1000 μm square regions of the tissue sections were analyzed using the Helios and Hyperion Tissue Imager (Standard BioTools). The instrument was tuned and calibrated using the 3-Element Full

(11) Single-cell spatial atlas of the aging human breastNature AgingMarch 31, 2026Pulkit Gupta, Eric Lee, Neus Masqué Soler, Ellen Schrader, Xiao Qian Wang, Shimrit Mayer, Cristina Flores, Sean Beatty, Andrew Roth, Samuel Aparicio, et al.including conjugation of platinum56 and bismuth57,58 isotopes. Finally, stained tissues were ablated with a Hyperion+ Imaging Mass Cytometer (Standard BioTools), and intensities were quantified using time-of-flight mass

(12) Inhaled Angiopoietin‐Like 4 Antisense Oligonucleotide Therapy for Lung Injury and FibrosisAdvanced ScienceMarch 23, 2026Haiyang Fan, Yuanyang Tan, Junhang Zhang, Xiaoya Liu, Jing Qu, Damien Chua, Hong Sheng Cheng, Joseph Han Sol Kim, Yu Xuan Liu, Changfei Qin, et al.ddH2O, and air‐dried for over 20 min. Imaging was performed using an imaging mass cytometer (Fluidigm Hyperion, Standard BioTools Inc., MA, USA). Quantitative fluorescence analysis was performed by ImageJ (version:

(13) Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS-chemokine-myeloid axisSci AdvMarch 13, 2026Bruno Beernaert, Rose L. Jady-Clark, Parin Shah, Erik Ramon-Gil, Nora M. Lawson, Zack D. Brodtman, Somnath Tagore, Frederik Stihler, Alfie S. Carter, Shannique Clarke, et al.slides were washed and left to dry, ready for laser ablation. Image acquisition was performed using the Hyperion Fluidigm (Standard BioTools). Cell segmentation on resulting images was performed using the OPTIMAL

(14) Peritoneal macrophages regulate distal wound healing via endocrine release of plasma fibronectinJ Clin InvestMarch 12, 2026Lilian Salm, Simone N. Zwicky, Daniel Spari, Tural Yarahmadov, Marie Siwicki, Fernanda Vargas e Silva Castanheira, Jonas Zbinden, Deborah Stroka, Joel Zindel, Antoine Dufour, et al.airflow hood. Sample acquisition on imaging mass cytometer. Images were acquired on a Standard BioTools Hyperion Imaging System with the CyTOF 7 software operated by the IMC Platform at the University of Bern and Inselspital. Quality

(15) Deep Learning Enabled 3D Multi-Omic Analysis Reveals Molecular Signatures of Heterogeneous Response to Chemotherapy in Pancreatic CancerbioRxivMarch 5, 2026André Forjaz, Hengameh Mojdeganlou, Alens Valentin, Meredith Wetzel, Dmitrijs Lvovs, Atul Deshpande, Sarah M. Shin, Sujan Piya, Kimal I Rajapakshe, Paola A Guerrero, et al.minutes at RT. Finally, slides were washed in Maxpar water and then air dried before being loaded in the Hyperion Imaging Plus System (Standard BioTools; RRID: SCR_023195) for image acquisition at the Johns Hopkins

(16) Cytometric Atlas of Combination Immunotherapy in Pancreatic Cancer: Blood-Based Signatures Reveal Vaccine and Checkpoint Inhibitor ResponsesCancer Immunol ResMarch 4, 2026Dimitrios N. Sidiropoulos, Zhehao Zhang, Jennifer N. Durham, Soren Charmsaz, Nicole E. Gross, Jae W. Lee, Yanyi Sun, Susheel Perikala, Joseph A. Tandurella, Dmitrijs Lvovs, et al.temperature. After another wash in Maxpar water for 5 minutes, slides were air-dried and loaded into the Hyperion Imaging Plus System (Standard BioTools) at the Johns Hopkins Mass Cytometry Facility. Selected representative

(17) A randomized phase II study: CRS207/GVAX plus anti-PD1 and anti-CTLA4 recruits mesothelin- and mKRAS-specific T cells into PDAC: A phase II trial of combined CRS207/GVAX and ICI in PDACCancer Immunol ResMarch 4, 2026Katherine M. Bever, Amanda L. Huff, Ludmila Danilova, Meredith Wetzel, Joseph A. Tandurella, Jennifer N. Durham, Tingchang Wang, Jae W. Lee, Erin M. Coyne, Janelle M. Montagne, et al.and used as a tissue counterstain. The slides were air dried and ablated for data acquisition using Hyperion PLUS™ at Johns Hopkins Mass Cytometry Facility. Images were segmented into single-cell dataset using

(18) Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen ExposureAdvanced ScienceMarch 1, 2026Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, et al.at 4°C before and after data acquisition. Tissue ablation was performed using the Standard BioTools Hyperion imaging mass cytometer in the MDACC North Campus Flow Cytometry and Cellular Imaging Core Facility. 4.5

(19) Computational Modeling of Cellular Influence Delineates Functionally Relevant and Distinct Cellular Neighborhoods in Primary and Metastatic Pancreatic Ductal AdenocarcinomaCancer Immunology ResearchFebruary 26, 2026Yeonju Cho, Jae W. Lee, Sarah M. Shin, Alexei G. Hernandez, Xuan Yuan, Jowaly Schneider, Jody E. Hooper, Laura D. Wood, Elizabeth M. Jaffee, Atul Deshpande, et al.used for IMC is provided in Supplementary Table S2. After staining, images were acquired using the Hyperion Imaging System (Standard BioTools) at the Johns Hopkins Mass Cytometry Facility. IMC provides high-dimensional spatial

(20) Resolving Sialylated N-Glycans and Immune Cell Landscapes Using a Unified Same-Section IMC–MSI WorkflowbioRxivFebruary 25, 2026Jake Griner, Reto Gerber, Mark D. Robinson, Carsten Krieg, Silvia Gugliettawith intercalator-Ir. Regions of interest ( ROI, ~1,300 μm × 1,300 μm) were acquired on the Helios/Hyperion Tissue Imager (Standard BioTools). Instrument performance was verified with the 3-Element tuning slide,

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