Human IL6 / Interleukin-6 Protein 10395-HNAE from Sino Biological, Inc.

Product Specs
ItemHuman IL6 / Interleukin-6 Protein
CompanySino Biological, Inc.
Price $148.00Supplier Page View Company Product Page
Catalog Number10395-HNAE
Activity1. Immobilized Human IL-6 (Cat:10395-HNAE) at 2 µg/mL (100 µL/well) can bind Human IL-6R hFc(Cat:10398-H02H), the EC50 of Human IL-6R hFc(Cat:10398-H02H) is 3.0-10.0 ng/mL. 2. Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.1-0.8 ng/mL. 3. Loaded Recombinant Human IL-6R Protein, His Tag (Cat. No. 10398-H08H) on HIS1K Biosensor, can bind Recombinant Human IL-6 Protein (Cat. No. 10395-HNAE) with an affinity constant of 75.9 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 4.Immobilized Recombinant Human IL-6 protein (Cat: 10395-HNAH) at 10 µg/mL (100 µl/well) on Recombinant Human IL6ST / gp130 / CD130 Protein (ECD, Fc Tag) (Cat: 10974-H02H) precoated (5 µg/mL, 100 µL/well) can bind Recombinant Human IL-6R Protein (His & AVI Tag), Biotinylated (Cat: 10398-H49H-B), the EC50 is 4-12 ng/mL (Routinely tested). 5.Immobilized Recombinant Human IL-6 protein (Cat: 10395-HNAH) at 10 µg/mL (100 µl/well) on Recombinant Rhesus IL6ST / gp130 Protein (Fc Tag) (Cat: 90275-C02H) precoated (5 µg/mL, 100 µL/well) can bind Recombinant Human IL-6R Protein (His & AVI Tag), Biotinylated (Cat: 10398-H49H-B), the EC50 is 5-15 ng/mL (Routinely tested)
Size20 µg
FormatLyophilized from sterile PBS, pH 7.4
Source/Expression SystemE. coli
Molecule NameIL6
SpeciesHuman
Molecular WeightThe recombinant human IL6 consists of 184 amino acids and predicts a molecular mass of 20.95 kDa. It migrates as an approximately 19.7 kDa band in SDS-PAGE under reducing conditions
TypeRecombinant protein
Purity≥ 95 % as determined by SDS-PAGE
Conjugate/TagUnconjugated

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) CD44 is a macrophage receptor for TcdB from Clostridioides difficile that via its lysine-158 succinylation contributes to inflammationGut microbesDecember 1, 2025Chen Z, Zhang W, Wang D, Luo R, Yao Y, Tao X, Li L, Pan Q, Sun X.Silicon Valley, CA, USA). Human IL-1β and IL-6 were purchased from SinoBiological (Cat# 10139-H07E; Cat# 10395-HNAE). To simulate the effects of macrophages located within the intestinal epithelium on intestinal epithelial cells

(2) Elevated SNHG15 empowers keratinocytes hyperproliferation through activation of STAT3/Cyclin D1 axis in psoriasisActa Pharmaceutica Sinica BOctober 17, 2025Lipeng Tang, Guanzhuo Li, Jiameng Chang, Haiyan Xian, Yanjie Liu, Luping Lin, Zixin Dai, Zhenting Liu, Xinmin Qiu, Bowen Zhang, et al.si-NC or si-SNHG15 (lnc3170302020131) were purchased from RiboBio company (Guangzhou, China). IL-6 (10395-HNAE), IL-1β (10139-HNAE), TNF-α (10602-HNAE), IL-22 (13059-HNAE), and IL-17A (12047-HNAE) were acquired

(3) Secretogranin 2 binds LILRB4 resulting in immunosuppressionNature immunologySeptember 1, 2025Yang X, Huang R, Fang M, He Y, Xie J, Liu X, Zhang C, Lou Q, Deng M, Xiong W, et al.BSA or SCG2 for 4 h. These cells were then stimulated with 20 μg ml−1) human IL-6 (Sino Biological, 10395-HNAE) or mouse IL-6 (Sino Biological, 50136-MNAE) for the indicated times, respectively. The cells were washed

(4) The fibrin-derived peptide FX06 protects human pulmonary endothelial cells against the COVID-19-triggered cytokine stormFrontiers in ImmunologyJune 19, 2025Zhiran Wang, Dmitrii Lebedev, Simeng Li, Sudharshan Rao, Kevin Wu, Lorcan Doyle, Kieran Wynne, Alfonso Blanco, Margaritha M. Mysior, Jeremy C. Simpson, et al.IL-1 Alpha,Sino Biological,10128-HNCH,20 IL-1 Beta,Sino Biological,10139-HNAE,10 IL-6,Sino Biological,10395-HNAE,50 IL-8,Sino Biological,10098-HNAE,20 TNF-Alpha,Sino Biological,10602-HNAE,100 IL-10,Sino Biological,10947-HNAE,20 IL-18,Sino Biological

(5) Human induced pluripotent stem cells derived neutrophils display strong anti-microbial potenciesCell RegenMarch 21, 2025Xing Hu, Baoqiang Kang, Mingquan Wang, Huaisong Lin, Zhiyong Liu, Zhishuai Zhang, Jiaming Gu, Yuchan Mai, Xinrui Guo, Wanli Ma, et al.TPO(13194-H08B-100; Sino Biological Inc.), 50 ng/mL Flt3L (300–19–100; PeproTech), and 10 ng/mLl IL6 (10395-HNAE-100; Sino Biological Inc.). Basal medium (BM): DMEM/F12 (GIBCO) + 1% penicillin–streptomycin (Hyclone)

(6) The antibody repertoire of autoimmune sensory neuronopathies targets pathways of the innate and adaptative immune system. An autoantigenomic approachJournal of Translational AutoimmunityJanuary 30, 2025Christian P. Moritz, Yannick Tholance, Nadia Boutahar, Coralie Borowczyk, Anne-Emmanuelle Berger, Stéphane Paul, Jean-Christophe Antoine, Jean-Philippe CamdessanchéIn detail, we coated ELISA plates with recombinant human IL-6 (0.3 μg/mL, Sino Biological, reference 10395-HNAE) or human IFN-γ (2 μg/mL) in 0.1 M carbonate/bicarbonate, pH 9.6, without glycerol. For IFN-γ, two different

(7) S1PR3-driven positive feedback loop sustains STAT3 activation and keratinocyte hyperproliferation in psoriasisCell death & diseaseJanuary 20, 2025Lian P, Li L, Lu R, Zhang B, Wazir J, Gu C, Ma B, Pu W, Cao W, Huang Z, et al.(Thermo Fisher Scientific) at 37 °C in 5% CO2. Cells were treated with 25 μg/mL IL-6 (Sino Biological, 10395-HNAE) or 25 μg/mL IL-22 (Sino Biological, 13059-HNAE). Additional treatments included FTY720 (MedChemExpress,

(8) Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancerNature communicationsSeptember 9, 2024Hung CH, Wu SY, Yao CD, Yeh HH, Lin CC, Chu CY, Huang TY, Shen MR, Lin CH, Su WC.

(9) Upregulated SKP2 Empowers Epidermal Proliferation Through Downregulation of P27 Kip1Annals of DermatologyMay 17, 2024Lipeng Tang, Bowen Zhang, Guanzhuo Li, Xinmin Qiu, Zixin Dai, Hongying Liu, Ying Zhu, Bing Feng, Zuqing Su, Wenhui Han, et al.stimulate HaCaT cells for inducing hyperproliferation of keratinocytes. IL-17A (12047-HNAE), IL-6 (10395-HNAE) and TNF-α (10602-HNAE) were purchased from Sino Biological Inc. (Beijing, China). SKP2 silencing The

(10) IL6-STAT3-C/EBPβ-IL6 positive feedback loop in tumor-associated macrophages promotes the EMT and metastasis of lung adenocarcinomaJournal of Experimental & Clinical Cancer ResearchFebruary 29, 2024Zhengyang Hu, Qihai Sui, Xing Jin, Guangyao Shan, Yiwei Huang, Yanjun Yi, Dejun Zeng, Mengnan Zhao, Cheng Zhan, Qun Wang, et al.(BD Biosciences CA, USA). Activators and inhibitors Recombinant human IL-6 protein: (Sino Biological, 10395-HNAE, Beijing, China), recombinant mouse IL-6 protein: (Sino Biological, 50136-MNAE, Beijing, China), IL-6 neutralizing antibody

(11) Generation and characterization of iPS cell line (SYSUSHi002-A) from PBMCs of an AML patient with TP53 mutationStem cell researchDecember 1, 2023Yuan L, Wang Y, Xie R, Lin D, Wang X.

(12) Therapeutic potency of compound RMY-205 for pulmonary fibrosis induced by SARS-CoV-2 nucleocapsid proteinCell chemical biologyMarch 16, 2023Zhang ZY, Ju CY, Wu LZ, Yan H, Hong WB, Chen HZ, Yang PB, Wang BR, Gou T, Chen XY, et al.,Thermo Fisher Scientific,Cat#62247 TGF-β,Cell Signaling Technology,Cat#8915LC Human IL-6,Sino Biological,Cat#10395-HNAE Human CCL2,Sino Biological,Cat# 10134-H08Y Human IL-8,MCE,Cat#HY-P9379 Human CXCL10,MCE,Cat# HY-P7226 GoTaq qPCR Master Mix

(13) Novel genetic regulators of fibrinogen synthesis identified by an in vitro experimental platformJournal of thrombosis and haemostasis : JTHMarch 1, 2023Dobson DA, Holle LA, Lin FC, Huffman JE, Luyendyk JP, Flick MJ, Smith NL, de Vries PS, Morrison AC, Wolberg AS.RSM. Fibrinogen-enriched supernatant was collected 24 hours later. For IL-6 treatment, IL-6 (catalog #10395-HNAE, Sino Biological, Houston, TX) was added to fresh OptiMEM RSM (50 ng/mL final) after the 48-hour transfection.

(14) Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinomaCell death & diseaseMay 25, 2022Zheng ZY, Chu MY, Lin W, Zheng YQ, Xu XE, Chen Y, Liao LD, Wu ZY, Wang SH, Li EM, et al.(PHG0311) were obtained from Thermo Fisher Scientific. OSM (10452-HNAH) and human recombinant IL-6 (10395-HNAE) were purchased from Sino Biological Inc. (Beijing, China). X-gal (0428-1 G) was purchased from Maygene

(15) Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entryCell metabolismMarch 1, 2022Li Z, Peng M, Chen P, Liu C, Hu A, Zhang Y, Peng J, Liu J, Li Y, Li W, et al.10108-H05H Human IL-4,Sino Biological Company,Cat. 11846-HNAE Human IL-6,Sino Biological Company,Cat. 10395-HNAE Human IFN-γ,Sino Biological Company,Cat. 11725-HNAS Human TNF-α,Sino Biological Company,Cat. 10602-HNAE ,, Critical

(16) Curcumin reverses hepatic epithelial mesenchymal transition induced by trichloroethylene by inhibiting IL-6R/STAT3Toxicology mechanisms and methodsOctober 1, 2021Cao W, Zhang Y, Li A, Yu P, Song L, Liang J, Cao N, Gao J, Xu R, Ma Y, et al.

(17) MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasisAutophagyOctober 1, 2021Deng R, Zhang HL, Huang JH, Cai RZ, Wang Y, Chen YH, Hu BX, Ye ZP, Li ZL, Mai J, et al.

(18) Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor MicroenvironmentMolecular cellJune 18, 2020Hou PP, Luo LJ, Chen HZ, Chen QT, Bian XL, Wu SF, Zhou JX, Zhao WX, Liu JM, Wang XM, et al.

(19) Interleukin-6 Therapy Improves Intestinal Recovery Following IschemiaThe Journal of surgical researchJuly 1, 2019Te Winkel JP, Drucker NA, Morocho BS, Shelley WC, Markel TA.

(20) The anti-inflammatory NHE-06 restores antitumor immunity by targeting NF-κB/IL-6/STAT3 signaling in hepatocellular carcinomaBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapieJune 1, 2018Lu X, Wo G, Li B, Xu C, Wu J, Jiang C, Wei J.

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Human IL6 / Interleukin-6 Protein 1

Human IL6 / Interleukin-6 Protein from Sino Biological, Inc.

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Sino Biological, Inc.

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Human IL6 / Interleukin-6 Protein from Sino Biological, Inc.

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