Human IL18 / IL-18 Protein 10119-HNCE from Sino Biological, Inc.

Product Specs
ItemHuman IL18 / IL-18 Protein
CompanySino Biological, Inc.
Price $448.00Supplier Page View Company Product Page
Catalog Number10119-HNCE
Size100 µg
Conjugate/TagN-cleavage
Purity> 95 % as determined by SDS-PAGE. > 95 % as determined by SEC-HPLC
TypeRecombinant protein
Molecular WeightThe recombinant human IL18 consists 157 amino acids and predicts a molecular mass of 18.2 kDa
SpeciesHuman
Molecule NameIL18
Source/Expression SystemE. coli
NCBI Full Gene Nameinterleukin 18
NCBI Gene AliasesIGIF, IL-18, IL-1g, IL1F4
Activity1.Measured by its ability to induce IFN-gamma secretion by KG-1 human acute myelogenous leukemia cells in the presence of TNF-alpha. The ED50 for this effect is typically 3-36 ng/ml. 2.Loaded Recombinant Human IL-18R beta / IL-18RAP Protein, hFc & AVI Tag (Cat. No. 10176-H41H-B) on ProA Biosensor, can bind Recombinant Human IL-18Rα Protein, His Tag (Cat. No. 11102-H08H) (Premixed with Human IL-18 Protein, Tag Free, Cat. No. 10119-HNCE) with an affinity constant of 7.7nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 3.Recombinant Human IL-18BP Protein, hFc Tag (Cat. No. 10357-H02H) captured on Protein A chip can bind Recombinant Human IL-18 Protein (Cat. No. 10119-HNCE) with an affinity constant of 14.9 pM as determined in an SPR assay (Biacore 8K) (Routinely tested). 4.Recombinant Human IL-18R beta / IL-18RAP Protein, hFc Tag (Cat. No. 10176-H02H) captured on Protein A chip can bind Recombinant Human IL-18 Protein (Cat. No. 10119-HNCE) (Premixed with Recombinant Human IL-18Rα Protein, His Tag, Cat. No. 11102-H08H) with an affinity constant of 12.85 nM as determined in an SPR assay (Biacore T200) (Routinely tested). 5.Recombinant Human IL18BP Protein (Fc Tag) (Cat: 10357-H02H) captured on Protein A chip, can bind Recombinant Human IL18 / IL-18 Protein (Cat: 10119-HNCE) with an affinity constant of 59.650 pM as determined in an SPR assay (Biacore T200) (Routinely tested). 6.Recombinant Human IL18 / IL-18 Protein (Cat: 10119-HNCE) immobilized on CM5 chip, can bind Recombinant Human IL-18Rα Protein (ECD, Fc & AVI Tag), Biotinylated (Cat: 11102-H41H-B) with an affinity constant of 71.320 nM as determined in an SPR assay (Biacore T200) (QC tested)
FormatLyophilized from sterile PBS, pH 7.4

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Structure-Guided Stapling of Dimeric Conformations and Linker Engineering Enhance Thermostability and Fine-Tune Activity of Bispecific VHH Cytokine AgonistsAntibodies (Basel)September 1, 2025Raphael Trenker, Deepti Rokkam, Andrew Morin, Priyanka Balasubrahmanyam, Verenice Paredes, Ivan Cheng, Rene de Waal Malefyt, Martin Oft, Patrick Lupardus, Sandro Vivonaand Purification Human IL-2 and IL-18 were purchased from Shenandoah (500-01) and Sino Biological (10119-HNCE), respectively. IL-18Rα and IL-18Rβ ECDs fused to human Fc for SPR experiments were purchased from Sino Biological

(2) The fibrin-derived peptide FX06 protects human pulmonary endothelial cells against the COVID-19-triggered cytokine stormFrontiers in ImmunologyJune 19, 2025Zhiran Wang, Dmitrii Lebedev, Simeng Li, Sudharshan Rao, Kevin Wu, Lorcan Doyle, Kieran Wynne, Alfonso Blanco, Margaritha M. Mysior, Jeremy C. Simpson, et al.,Sino Biological,10098-HNAE,20 TNF-Alpha,Sino Biological,10602-HNAE,100 IL-10,Sino Biological,10947-HNAE,20 IL-18,Sino Biological,10119-HNCE,50 IL-1 RA,Sino Biological,10123-HNAE,50 IP-10,Sino Biological,10768-HNAE,150 IFN-gamma,Sino Biological,11725-HNAS,50 Recipes

(3) A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasiseLifeJune 11, 2021Li J, Qin X, Shi J, Wang X, Li T, Xu M, Chen X, Zhao Y, Han J, Piao Y, et al.were treated with 5 ng/mL murine recombinant IL-18 protein or 5 ng/mL human recombinant IL-18 protein (10119-HNCE, Sino Biological, Beijing, China) or 5 ng/mL murine recombinant IL-20 protein (TP723795, Origene, Rockville,

(4) Roflumilast Reduced the IL-18-Induced Inflammatory Response in Fibroblast-Like Synoviocytes (FLS)ACS omegaJanuary 26, 2021Zhong B, Guo S, Yang Z, Han L, Du J, Chen J, Dun X, Wang G.serum (FBS) and 1% penicillin–streptomycin (P/S). Cells were stimulated with IL-18 (10 ng/mL, Cat# 10119-HNCE, SinoBiological)6,7,10 in the presence or absence of 5 and 10 μM roflumilast (Cat# A10804, Adooq Bioscience).16,18 4.2

(5) Endometrial inflammasome activation accompanies menstruation and may have implications for systemic inflammatory events of the menstrual cycleHuman reproduction (Oxford, England)June 1, 2020Azlan A, Salamonsen LA, Hutchison J, Evans J.

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Human IL18 / IL-18 Protein

Human IL18 / IL-18 Protein from Sino Biological, Inc.

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Sino Biological, Inc.

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Human IL18 / IL-18 Protein from Sino Biological, Inc.

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