Human IL6R / CD126 Protein (His Tag) 10398-H08H from Sino Biological, Inc.

Product Specs
ItemHuman IL6R / CD126 Protein (His Tag)
CompanySino Biological, Inc.
Price $338.00Supplier Page View Company Product Page
Catalog Number10398-H08H
Activity1. Immobilized Recombinant Human IL6 / Interleukin-6 Protein (Cat: 10395-HNAE) at 2µg/mL (100µL/well) can bind Recombinant Human IL6R / CD126 Protein (His Tag) (Cat: 10398-H08H),the EC50 is 8-24 ng/mL. 2. Measured by its ability to enhance the IL6 activity on M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 20-80 ng/mL. 3. Using the Octet RED System, the affinity constant (Kd) of IL-6R Protein, Human, Recombinant (His Tag) (Cat. 10398-H08H) bound Anti-IL6R Antibody (Cat. 10398-MM08) was 0.1 nM. 4. Loaded Recombinant Human IL-6R Protein, His Tag (Cat. No. 10398-H08H) on HIS1K Biosensor, can bind Recombinant Human IL-6 Protein (Cat. No. 10395-HNAE) with an affinity constant of 75.9 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested)
FormatLyophilized from sterile PBS, pH 7.4
Size100 µg
NCBI Gene AliasesCD126, HIES5, IL-1Ra, IL-6R, IL-6R-1, IL-6RA, IL6Q, IL6QTL, IL6RA, IL6RQ, gp80
NCBI Full Gene Nameinterleukin 6 receptor
Source/Expression SystemHEK293 Cells
Molecule NameIL6R
SpeciesHuman
Molecular WeightThe soluble form of recombinant human IL6R consists of 357 amino acids and has a predicted molecular mass of 40 kDa. In SDS-PAGE under reducing conditions, it migrates with an apparent molecular mass of 60-65 kDa due to glycosylation
TypeRecombinant protein
Purity≥ 90 % as determined by SDS-PAGE ≥ 95 % as determined by SEC-HPLC
Conjugate/TagC-His

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Beyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificitiesmAbsJanuary 1, 2022Yanakieva D, Pekar L, Evers A, Fleischer M, Keller S, Mueller-Pompalla D, Toleikis L, Kolmar H, Zielonka S, Krah S.(ACRO Biosystems, Cat: EGR-H5222) – 1.5 nM to 100 nM, human IL6R ECD-His Tag (Sino Biological, Cat: 10398-H08H) – 0.78 nM to 50 nM, and human NKG2D-His Tag (Sino Biological, Cat: 10575-H07B) – 0.78 nM to 50 nM.

(2) Chikusetsusaponin IVa Butyl Ester (CS-IVa-Be), a Novel IL6R Antagonist, Inhibits IL6/STAT3 Signaling Pathway and Induces Cancer Cell ApoptosisMolecular cancer therapeuticsJune 1, 2016Yang J, Qian S, Cai X, Lu W, Hu C, Sun X, Yang Y, Yu Q, Gao SP, Cao P.

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Human IL6R / CD126 Protein (His Tag)

Human IL6R / CD126 Protein (His Tag) from Sino Biological, Inc.

Description

Sino Biological, Inc.

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Human IL6R / CD126 Protein (His Tag) from Sino Biological, Inc.

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