Anti-IGHG1 antibodies are used in the immunodetection of the protein immunoglobulin heavy constant gamma 1 (G1m marker). In humans, the canonical protein has a reported length of 399 amino acid residues and a mass of 43.9 kDa. Its subcellular localization is in the cell membrane and is secreted. Up to 2 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the bone marrow and placenta. IGHG1 is known to be involved with adaptive immune responses. Post-translational modifications have been described, including glycosylation. The IGHG1 marker can be used to identify Memory B Cells.* Over 1500 citations in the literature describe the use of IGHG1 antibodies in research. Flow Cytometry is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4