Normal Goat IgG Control AB-108-C from R&D Systems, a Bio-Techne Brand

Product Specs
ItemNormal Goat IgG Control
CompanyR&D Systems, a Bio-Techne Brand
Price $139.00Supplier Page View Company Product Page
Catalog NumberAB-108-C
TargetIgG
ReactivityGoat
Quantity1 mg
Conjugate/TagUnconjugated
ApplicationsControl
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose
IsotypeIgG
HostGoat
ClonalityPolyclonal
ConcentrationLYOPH
PurityProtein A or G purified
Antibody TypeIsotype Controls
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution
NCBI Full Gene Nameimmunoglobulin heavy constant gamma 1 (G1m marker)

Specifications/Features

Available conjugates: Unconjugated

Questions and Answers

Can this normal goat IgG control be used as an isotype control in flow cytometry experiments?

Yes, the normal goat IgG control has been utilized in flow cytometry applications, as demonstrated in studies where it served as an isotype control alongside specific antibodies to assess the specificity of staining in various cellular contexts, including T-cell analysis ().

Is there any evidence of this product being used in vivo for antibody neutralization studies?

Yes, the normal goat IgG control has been used in vivo as a control for neutralizing antibodies in studies, such as in a renal ischemia-reperfusion injury model, where it was administered to assess the effects of specific antibody treatments on renal function and inflammation ().

How does this goat IgG control perform in the context of cancer research?

The normal goat IgG control has been employed in cancer research, specifically in studies examining the role of interleukin-8 in breast cancer dissemination, where it was used to control for non-specific binding in antibody assays ().

What is the significance of using this goat IgG control in immunological assays?

The normal goat IgG control is significant in immunological assays as it helps to establish baseline levels of non-specific binding, ensuring that observed effects in assays, such as those measuring cytokine levels or cell adhesion, are attributable to specific interactions rather than background noise ().

R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

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(2) ALKBH5 facilitates Srgn stability via m6A demethylation to disrupt blood-testis barrier integrity in the high-fat diet miceCellular and Molecular Life SciencesMarch 30, 2026Tian Du, Liangyu Yao, Wenhua Wang, Zhou Li, Jie Dong, Zheng Zhou, Chengyu Shi, Xie Ge, Rujun Ma, Li Chen, et al.anti-TNF-α antibody (R&D Systems, AF-410-SP) at 10 ng/mL. Cells treated with Anti-IgG antibody (R&D Systems, AB-108-C) were used as the control. The cells were treated with the neutralizing antibodies for 24 h, and then

(3) In Vitro Enhanced Performance of Human Platelet Lysate Gel Integrated with Mesoporous Silica Nanoparticle/Carboxymethyl Chitosan Composite Hydrogel: Structural Stability and Biological Activities for Chronic Wound HealingACS OmegaMarch 24, 2026Tareerat Lertwimol, Suwitchaya Jankam, Setthawut Kitpakornsanti, Weerachai Singhatanadgit, Wanida Janvikulcontrol, xPMC/hPLG spots were pretreated for 45 min with an isotype control goat IgG antibody (0.2 μg/mL; AB-108 C, R&D Systems). 2.13 Statistical Analyses Statistical analyses were performed using SPSS software (version

(4) Inflammatory Mediators Both Directly and Indirectly Promote Microglial ProliferationGliaMarch 19, 2026Brady P. Hammond, Eugene Hahn, Kelly V. Lee, Bradley J. Kerr, Jason R. Plemelgoat anti‐IL3 (10 μg/mL; R&D Systems AF‐403) and its isotype control goat IgG (10 μg/mL; R&D Systems AB‐108‐C) and incubated at 37°C for 1 h before treating microglia for 72 h. 4.12 Statistical and Image Analyses We

(5) Intracellular Osteopontin of Macrophages Promotes Carotid Plaques Formation by Inducing Foam Cells and Releasing Proinflammatory CytokinesJournal of the American Heart AssociationMarch 17, 2026Han Nie, Geng Liu, Wei‐Hang Lu, Chen Yan, Zi‐Sheng Huang, Wei‐Min Zhou, Tao‐Sheng LiR&D Systems) was added to the culture medium for OPN neutralization, and normal goat IgG (2 μg/mL; AB‐108‐C; R&D Systems) was used as a negative control. After 48 hours, cells were collected for analysis. To

(6) Sigma-1 receptor regulates HIV-1 and methamphetamine-induced endothelial/pericyte barrier impairment via strain-specific inflammatory responses and mitochondrial dysregulationJournal of NeuroinflammationMarch 6, 2026Nikolai Fattakhov, Silvia Torices, Sarah Becker, Joelle-Ann Joseph, Sarah Schmidlin, Alex Ngo, Adesuwa Okoro, Oandy Naranjo, Michal Toborekantibody (8 µg/mL; R&D Systems, Cat# AF-279-NA) or with normal goat IgG as a control (R&D Systems, Cat# AB-108-C). Cell viability assay HBVP viability was assessed using the Cell Counting Kit 8 (CCK-8) assay (Abcam,

(7) Assessing Aβ-independent effects of Module 42 on immune function in vitroAlzheimers DementFebruary 25, 2026Ishita Ajith, Souvika Bakshi, Emma Mead, Opher Gileadi, Vittorio L. Katis, Paul E. Brennan, Emory‐Sage‐SGC‐Jax TREAT‐AD Center, Katerina O. Gospodinovamyeloid cells 2 (TREM2)‐activating antibody (5 µg/mL, AF1828, R&D Systems) or IgG control (5 µg/mL, AB‐108‐C, R&D Systems) for 5 min at 37°C, 5% CO2. Following treatments, cells were lysed in kit‐provided lysis

(8) Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent ferroptosis and Wnt suppressionCell Death DiscoveryFebruary 25, 2026Vivek Khanal, Madeline Carroll, Fatemeh Moradi, Jayden Carter, Ying Zhong, Chikkamagaluru G. Shashank, Amy Y. Sato, Ryan M. Allen, Umesh D. Wankhade, Neha S. Doleab150080, Alexa Fluor® 594). Corresponding nonimmune IgGs (Abcam, ab172730 for rabbit and R&D systems, AB-108-C for goat) were used as negative controls. H&E staining was performed to assess viable osteocytes. Bone

(9) Comprehensive Cytogenetic and Genomic Profiling of the Murine AML12 (Alpha Mouse Liver 12) Hepatocyte Cell LineCellsFebruary 24, 2026Darine Y. Asar, Stefanie Kankel, Diandra T. Keller, Katharina S. Hardt, Sarah K. Schröder-Lange, Eva M. Buhl, Thomas Liehr, Ralf Weiskirchenanti-HNFα antibody (sc-6556, Santa Cruz Biotechnology, shown in (green) or goat IgG control (R&D Systems, #AB-108-C) (B). Nuclei were counterstained with DAPI (blue). HNF4α-positive staining was mainly localized in the

(10) Spatial characterisation of TREM2 expression in actively demyelinating multiple sclerosis lesions supports its key roles in lipid metabolic pathwaysActa Neuropathologica CommunicationsFebruary 16, 2026Yvonne A Aguirre Candia, Ekaterina Aladyeva, William J Boyden, Bryan Bollman, Lara Rogerson-Wood, Danielle S Davies, Andrew J Affleck, Michael E Buckland, Oscar Harari, Laura Piccio, et al.(21E10),1:200 Mouse anti-human TREM2,Microglia,N/A (T22),1:200 Goat IgG Control,Isotype control,"R&D Systems, USA (AB-108-C)",1:200 Secondary antibody (Alexa Fluor Conjugate),Reactivity,Source (Cat#),Dilution Donkey anti-rabbit

(11) TLR8 agonists remodel the tumor immune microenvironment through PF4-dependent T cell recruitment and ancillary mechanismsCancer Immunol ImmunotherFebruary 12, 2026Qikai Zhou, Zhixue Wang, Yixian Cao, Zhengheng Zheng, Wen Li, Zifeng Fu, Wenqin Luo, Wei-Qiang Gao, Bin Mapretreated with motolimod (100 nM), anti-PF4 antibody (R&D Systems, #AF595), or control IgG (R&D Systems, #AB-108-C) and co-cultured with activated T cells in Transwell inserts (Corning, #3422). Migrated cells were stained

(12) JAM-C prevents ocular fibrosis by suppressing the TAZ/KLF6 pathwayJournal of Advanced ResearchFebruary 1, 2026Min Chen, Wanhong Li, Yuxiang Du, Yuanlong Zhao, Ying Guo, Ying Li, Xiaolu Wang, Lijuan Huang, Xiaoling Zeng, Yihan Zhang, et al.Scientific). Cell lysates were incubated with JAM-C antibody (AF1189, R&D Systems, MN, USA), or IgG (AB-108-C, R&D Systems) at 4°C overnight, followed by Protein A/G-Sepharose (sc-2003, Santa Cruz, USA) incubation

(13) Inflammatory cytokines secreted from senescent periodontal ligament cells influence the osteocyte network in alveolar boneJBMR PlusJanuary 29, 2026Akimi Yamashita, Hirofumi Tenshin, SooHa Matsuki, Go Nishino, Shinetsetseg Ser-Od, Filippo Moenne Saito, Masahiro Hiasa, Eiji Tanaka(AF3244-SP), anti-SOST/sclerostin antibody (AF1589), rabbit control IgG (AB-105-C), goat control IgG (AB-108-C) from R&D Systems; anti-Cathepsin K (CTSK) antibody (11239-1-AP) from Proteintech; Dasanitib (SML2589)

(14) FGF21 Exacerbates Obesity-Induced Airway Hyperresponsiveness and FGFR1-Dependent Mast Cell Activation in MiceJournal of Inflammation ResearchJanuary 24, 2026Lulu Ren, Lingling Xuan, Jie Zhang, Wen Zhang, Zhuoling Anobese + IgG, lean + anti-FGF21, and obese + anti-FGF21. Anti-FGF21 antibody (AF3057) and control IgG (AB-108-C) were purchased from Bio-Techne. All mice were housed in static cages (5 mice/cage) at 22–24°C under

(15) EGFR-mutant transformed small cell lung cancer harbors intratumoral heterogeneity targetable with MEK inhibitor combination therapyJCI InsightJanuary 23, 2026Atsuko Ogino, Amir Vajdi, Xinmeng Jasmine Mu, Navin R. Mahadevan, Kenneth Ngo, Matthew A. Booker, Paloma Cejas, Jeffrey J. Okoro, Man Xu, Benjamin F. Springer, et al.LIF neutralizing antibody (AF-250-NA), IL-6 neutralizing antibody (AF-206-NA), and control antibody (AB-108-C) were purchased from R&D Systems. Human EGF recombinant protein was obtained from Life Technologies. Generation

(16) Human Liver Organoids as an Experimental Tool to Investigate Lipocalin-2 in Hepatic InflammationCellsJanuary 23, 2026Katharina S. Hardt, Robert F. Pohlberger, Diandra T. Keller, Eva M. Buhl, Florian W. R. Vondran, Anjali A. Roeth, Ralf Weiskirchen, Sarah K. Schröder-Lange(AF1757, R&D Systems) was diluted 1:100 in blocking buffer and incubated overnight at 4 °C. Goat IgG (AB-108-C, R&D Systems) was used as a control at the same concentration. The following day, organoids were incubated

(17) Rapid Bone Formation and Remodeling via Vascular Infiltration of a Hydroxyapatite/Collagen Nanocomposite beneath the Calvarial PeriosteumBiomaterials and BiosystemsJanuary 22, 2026Hanae Arai, Masayoshi Uezono, Masanori Kikuchi, Hitoshi Amano, Chen Derong, Kazuhiro Aoki, Keiji Moriyamaantibody (1:99; ab2349, Abcam, Cambridge, UK). Negative controls were incubated with anti-goat IgG (1:99; AB-108-C, R&D Systems, Minneapolis, MN, USA) at the same concentration as the primary antibody subsequently,

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(20) Macrophage TRIM21 lactylation exacerbates infection-induced orchitis through enhancing STAT1-mediated CXCL9 and CXCL10 productionFrontiers in ImmunologyJanuary 14, 2026Wenjing Tang, Wenjie Chen, Na Li, Wei Li, Zhigang Lei, Wenhui Sun, Xuan Xie, Yihong Jiang, Ying Chen, Lei Xu, et al.the testis using a microsyringe. The control group received the same amount of LPS and isotype IgG (AB-108-C, R&D Systems, Minneapolis, MN, USA) injection. Following incision closure, mice were allowed to recover

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5/10/2017Goat IgG Isotype Control Juwen DuBoisWe were conducting an experiment in which we injected mice with a goat derived antibody in order to tests its ability to enhance recovery in a mouse model of multiple sclerosis. We used this Goat IgG ... Read Review