Anti-sirtuin 1 antibodies are used for the immunodetection of the protein encoded by the SIRT1 gene. In humans, the canonical protein has a reported length of 747 amino acid residues and a mass of 81.7 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. It is widely expressed across many tissue types. A member of the Sirtuin protein family, it is known to be involved with angiogenesis and carbohydrate metabolism and homeostasis. Post-translational modifications have been described, including methylation, acetylation, protein cleavage and phosphorylation. Other names for this target antigen include SIR2L1, SIR2alpha, NAD-dependent protein deacetylase sirtuin-1, NAD-dependent protein deacylase sirtuin-1, SIR2-like protein 1, and SIR2. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 1500 citations in the literature describe the use of sirtuin 1 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.