Novus Biologicals
Sirtuin 1/SIRT1 Antibody
NBP1-51641PE
1F3
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SIRT1 functions as a NAD-dependent deacetylase of p53. Here, we checked the time course effect of SIRT1 expression by chemoattractant.
Western Blot
Mouse Lysate
1:1000 prepared in 1x TBST
5% Skim milk
1:4000 prepared in 1x TBST
None
ECL
SIRT1, the human homolog of the S. cerevisiae Sir2 protein, functions as an NAD-dependent deacetylase of a number of nonhistone substrates including p53. In response to DNA damage, SIRT1 binds and deacetylates the p53 protein at c-terminal Lys382 residue and attenuate p53-mediated functions. In mammalian cells, SIRT1 appears to control the cellular response to stress by regulating the FOXO family of forkhead transcription factors. Here we checked the time course effect of SIRT1 expression by chemoattractant. We found time dependent increase of SIRT1 expression by chemoattractant.
This antibody works great for Western blot.
Highly recommended antibody for Western blot.