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Automated DNA/RNA Purification Sample Preparation Workstations
Maxwell RSC Instrument
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Maxwell RSC Instrument
Maxwell RSC Instrument
Maxwell RSC Instrument from Promega
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Citations:
(849)
Figures:
(1)
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Maxwell RSC Instrument
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Description
The Maxwell RSC Instrument is a platform for automated extraction of nucleic acid from a range of sample types. Extraction methods use sample lysis and binding to paramagnetic particles followed by washing steps and elution.
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
Maxwell RSC Instrument
Company
Promega
Price
Supplier Page
View Company Product Page
Catalog Number
AS4500
Quantity
EA
Processing Time
30 to 60 min (depending on sample type and method)
Capacity
Up to 16
Dimensions
(WxDxH) 330.2 x 345.2 x 299.7 mm (13 x 13.6 x 11.8 in)
UV Lamp
Avg. lifetime approximately 6,000 hrs
Molecular Weight
~85kDa
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Promega
2800 Woods Hollow Rd
Madison
,
WI
53711
United States
Phone
: Tel: +1 (608) 274-4330
Fax: +1 (608) 277-2516
Email: custserv@promega.com
techserv@promega.com
Company Profile
Website:
http://www.promega.com
Citations (849)
(61)
Centriflaken: An automated data analysis pipeline for assembly and in silico analyses of foodborne pathogens from metagenomic samples
PLoS One
December 23, 2025
Kranti Konganti, Julie A. Kase, Narjol Gonzalez-Escalona
enriched agricultural water sample was extracted using the Maxwell RSC
Cultured Cell
DNA Kit with a
Maxwell RSC Instrument
(
Promega Corporation
, Madison, WI, USA) according to the manufacturer’s instructions DNA concentration
(62)
Claudin‐18 expression in gastric type adenocarcinoma and HPV ‐associated adenocarcinoma of the uterine cervix
Histopathology
December 22, 2025
Nobuko Yasutake, Yuki Yokawa, Takehiro Tanaka, Riri Mishima, Misato Komamizu, Ryosuke Kuga, Rina Jiromaru, Shinichiro Kawatoko, Kenzo Sonoda, Hideaki Yahata,
et al.
CLDN18
.2 mRNA Expression Total RNA was extracted from FFPE samples using a
Maxwell® RSC RNA FFPE Kit
and
Maxwell® RSC Instrument
(
Promega Corporation
, Madison, WI, USA) according to the manufacturer's protocol. RNA concentrations
(63)
Variant analysis and biochemical investigation in two siblings with late onset idiopathic secondary erythrocytosis: A case report
Medicine (Baltimore)
December 19, 2025
Vincenza Ylenia Cusenza, Beatrice Melli, Chiara Marraccini, Agnese Razzoli, Margherita Genitoni, Laura Albertazzi, Nesrine Gamal, Gaia Gavioli, Davide Nicoli, Enrico Farnetti,
et al.
peripheral blood sample using the
Maxwell® 16 LEV Blood DNA kit
(
Maxwell® 16 LEV Blood DNA Kit
) on the
Maxwell® RSC instrument
(
Promega Corporation
, Madison), according to the manufacturer’s specifications. DNA
amplification
by
(64)
Variant analysis and biochemical investigation in two siblings with late onset idiopathic secondary erythrocytosis: A case report
Medicine (Baltimore)
December 19, 2025
Vincenza Ylenia Cusenza, Beatrice Melli, Chiara Marraccini, Agnese Razzoli, Margherita Genitoni, Laura Albertazzi, Nesrine Gamal, Gaia Gavioli, Davide Nicoli, Enrico Farnetti,
et al.
peripheral blood sample using the
Maxwell® 16 LEV Blood DNA kit
(
Maxwell® 16 LEV Blood DNA Kit
) on the
Maxwell® RSC instrument
(
Promega Corporation
, Madison), according to the manufacturer’s specifications. DNA
amplification
by
(65)
Genome and transcriptome-wide association studies identify multiple novel loci for dementia with grain in Japanese
Journal of Human Genetics
December 17, 2025
Risa Mitsumori, Kouichi Ozaki, Yuko Saito, Daichi Shigemizu, Atsushi Iwata, Shigeo Murayama, Masahiro Akishita, Tomio Arai, Shumpei Niida, Kenji Toba
DNA from NCGG biobank was extracted from peripheral blood
leukocytes
by standard protocols using a
Maxwell RSC Instrument
and a
Maxwell RSC Buffy Coat DNA Kit
(
Promega
, Madison, WI, USA). Genomic DNA from TMIG was extracted
(66)
Effects of Long-Term Ocean Acidification Exposure on the Structural, Mineralogical, and Mechanical Properties of Sea Urchin (Echinometra spp.) Skeletons at a Natural Volcanic CO2 Seep
Environ Sci Technol
December 16, 2025
Callum J. Hudson, Jeffrey Jolly, Sean D. Connell, Timothy Ravasi, Ben P. Harvey
extracted from the tissue using Promega Maxwell RSC Tissue DNA Kits (
Promega
, USA) and the associated
Maxwell RSC Instrument
according to the manufacturer’s protocols. The extracted DNA concentration was measured by
fluorometry
(67)
Identification of Intronic Variants in NDUFA3 as a Cause of Leigh Syndrome by Whole Genome Sequencing and RNA Sequencing
Neurol Genet
December 11, 2025
Kohta Nakamura, Yoshihito Kishita, Ayumu Sugiura, Kokoro Ozaki, Yukiko Yatsuka, Naoyuki Matsumoto, Atsuko Okazaki, Holger Prokisch, Koichi Maruyama, Hiroyasu Iwasa,
et al.
RNA Sequencing
RNA was purified from patient-derived skin
fibroblasts
by the
Maxwell RSC simplyRNA Cells Kit
and a
Maxwell RSC Instrument
(
Promega
). mRNA was enriched using oligo (dT) beads and rRNA removed using the Illumina Ribo-Zero kit.
(68)
Identification of Intronic Variants in NDUFA3 as a Cause of Leigh Syndrome by Whole Genome Sequencing and RNA Sequencing
Neurol Genet
December 11, 2025
Kohta Nakamura, Yoshihito Kishita, Ayumu Sugiura, Kokoro Ozaki, Yukiko Yatsuka, Naoyuki Matsumoto, Atsuko Okazaki, Holger Prokisch, Koichi Maruyama, Hiroyasu Iwasa,
et al.
RNA Sequencing
RNA was purified from patient-derived skin
fibroblasts
by the
Maxwell RSC simplyRNA Cells Kit
and a
Maxwell RSC Instrument
(
Promega
). mRNA was enriched using oligo (dT) beads and rRNA removed using the Illumina Ribo-Zero kit.
(69)
A phage displaying an Aβ-interacting peptide mitigates neurotoxicity and prevents Aβ-driven gene expression changes
Front Mol Neurosci
December 10, 2025
Laura Maria De Plano, Luigi Chiricosta, Simone D'Angiolini, Alessandra Saitta, Alessandra Trainito, Serena Silvestro, Sabrina Conoci, Salvatore Oddo, Antonella Caccamo
of 12CIII1. Following treatment, cell pellets were collected, and total RNA was extracted using the
Maxwell® RSC instrument
according to the manufacturer’s instructions for the
Maxwell® RSC simplyRNA Cells Kit
(
Promega
, Madison,
(70)
Replicon-based genome-wide CRISPR knockout screening for the identification of host factors involved in viral replication
Nat Commun
December 10, 2025
Karen W. Cheng, Madhura Bhave, Andrew L. Markhard, Duo Peng, Karan D. Bhatt, Katherine A. Travisano, Josette V. Medicielo, Astrid Anaya, Sanae Lembirik, Leila Njoya,
et al.
Maxwell RSC Viral Total Nucleic Acid Purification Kit
(
Promega
,
AS1330
) and the automated Maxwell RSC extractor (
Promega
,
AS4500
). Briefly, 200 µL of TRIzol LS-treated sample were added to 200 µL of the kit’s lysis buffer and vortexed
(71)
Induction of immune education in type 1 diabetes through controlled allogeneic islet rejection at onset: a monocentric open-label pilot study
EClinicalMedicine
December 4, 2025
Lorenzo Piemonti, Andrea Mario Bolla, Amelia Caretto, Raffaella Melzi, Alessia Mercalli, Valeria Sordi, Paolo Monti, Paola Magistretti, Vito Lampasona, Ilaria Marzinotto,
et al.
12, 18 months; and 2, 3, 4, 5 years) using the Maxwell® RSC
miRNA
from Plasma and Serum kit with the
Maxwell® RSC Instrument
(
Promega
), according to manufacturer's instructions. All serum miRNAs underwent universal reverse transcription
(72)
Soil phosphate availability drives shifts between arbuscular mycorrhizal and ectomycorrhizal fungi in the dual mycorrhizal plant Quercus serrata
New Phytologist
December 1, 2025
Tatsuhiro Ezawa, Chika Mizukami, Anjar Cahyaningtyas, Mana Mukai, Kanehiro Kitayama
Multi‐Beads Shocker (Yasui Kikai), and DNA was extracted and purified from c. 100 mg FW of ground sample by
Maxwell RSC Instrument
using
Maxwell RSC PureFood GMO and Authentication Kit
(
Promega
, Tokyo, Japan) according to the manufacturer's
(73)
Infection Dynamics and Host Biomarker Identification for Spotty Liver Disease in Chickens
Vet Sci
November 29, 2025
Helen James, Emily Gan, Robert J. Moore, Daniel M. Andrews, Thi Thu Hao Van
with C. hepaticus-specific primers as described by Van et al. 2017 [24]. DNA was extracted using the
Maxwell® RSC instrument
with the
Maxwell® RSC PureFood GMO and Authentication Kit
(
Promega
, Madison, WI, USA), following the
(74)
Efficacy of nutraceutical supplements containing Passiflora incarnata L., Withania somnifera (L.) Dunal and Taraxacum officinale (L.) weber ex F.H.Wigg. on markers of inflammation, oxidative stress and gut microbiota in senior dogs
Frontiers in Veterinary Science
November 27, 2025
Roberto Ciarcia, Consiglia Longobardi, Valeria Iervolino, Tommaso Manenti, Francesco Ferrucci, Iolanda Veneruso, Valeria D’Argenio, Antonio Rubino, Alessandra Pelagalli, Pietro Lombardi,
et al.
h, frozen at −80 °C until analysis. Genomic DNAs were obtained using the RSC Blood DNA kit and the
Maxwell RSC instrument
(both from
Promega
, Madison, WI, USA), as previously reported (26). Two blank/negative samples were
(75)
The host range of generalist and specialist phages in capsule-diverse Klebsiella hosts is driven by the evolvability of receptor-binding proteins
PLOS Biology
November 26, 2025
Celia Ferriol-González, Pilar Domingo-Calap
5-Kit (Zymo) for the passages and using Maxwell PureFood GMO and Authentication Kit (Promega) with
Maxwell RSC Instrument
(
Promega
) for single plaques.
Sequencing
libraries were prepared using the Illumina Nextera XT DNA kit
(76)
Genomic landscape and molecular subtypes of primary central nervous system lymphoma
Blood Cancer Journal
November 26, 2025
Shengjie Li, Danhui Li, Zuguang Xia, Jianing Wu, Jun Ren, Yingzhu Li, Jiazhen Cao, Ying Sun, Chengxun Li, Wenjun Cao,
et al.
DNA (gDNA) was extracted via the
Maxwell RSC Blood DNA Kit
(
AS1400
,
Promega
) on a Maxwell RSC system (
AS4500
,
Promega
) following the manufacturer’s instructions. For FFPE tissue, total gDNA was extracted via the
(77)
NLRP3-induced systemic inflammation controls the development of JAK2V617F mutant myeloproliferative neoplasms
Nature Communications
November 26, 2025
Ruth-Miriam Koerber, Calvin Krollmann, Kevin Cieslak, Elisabeth Tregel, Maria L. Saenz, Tim H. Brümmendorf, Steffen Koschmieder, Martin Griesshammer, Ines Gütgemann, Conny K. Baldauf,
et al.
(IBL). Quantitative
RT–PCR
RNA was extracted from cells with the
Maxwell RSC simplyRNA Cells Kit
(
Promega
) on a
Maxwell RSC instrument
and mRNA reverse transcribed with the
RevertAid First Strand cDNA Synthesis Kit
(
Thermo Fisher Scientific
).
(78)
Olutasidenib for mutated IDH1 acute myeloid leukemia: final five-year results from the phase 2 pivotal cohort
Journal of Hematology & Oncology
November 14, 2025
Jorge Cortes, Antonio Curti, Pierre Fenaux, Brian A. Jonas, Jürgen Krauter, Pau Montesinos, Christian Récher, David C. Taussig, Eunice S. Wang, Justin Watts,
et al.
in PAXGene® tubes. Blood genomic DNA (gDNA) was isolated using the
Maxwell® RSC Blood DNA Kit
on the
Maxwell® RSC Instrument
(
Promega
, Madison, WI, USA), according to the manufacturer’s instructions. The yield of gDNA was assessed
(79)
Identification of poultry commensal bacteria with the ability to inhibit the growth of Salmonella enterica serovar Typhimurium in co-culture
BMC Microbiology
November 12, 2025
Zhixuan Feng, Valérie Dagenais, Valérie Leclerc, Clara Pigozzo, Jennifer Ronholm
incubation
period. The suspension was then transferred into the DNA extraction cartridge and placed in the
Maxwell® RSC instrument
(
Promega
, USA). The DNA was extracted using the pre-programmed “Blood DNA extraction” program. The DNA
(80)
Gut bacteria metabolize natural and synthetic steroid hormones via the reductive OsrABC pathway
Cell Host & Microbe
November 12, 2025
Christian Jacoby, Kaylie Scorza, Lia Ecker, Paola Nol Nol Bernardino, Alexander S. Little, Mary McMillin, Ramanujam Ramaswamy, Anitha Sundararajan, Ashley M. Sidebottom, Huaiying Lin,
et al.
processing. Cell pellets were thawed and total RNA from biological replicates were extracted using the
Maxwell RSC instrument
(
Promega
). Extracted RNA was quantified using Qubit, and integrity was measured using TapeStation (Agilent
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Maxwell RSC Instrument from Promega
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