
The ability to observe cellular processes and phenotypes in terms of spatial and morphological context is valuable in many research areas, from basic research to clinical development in areas like immuno-oncology, neurology, cardiovascular and infectious diseases. Novel platforms allow researchers to bridge the gap between high-resolution tissue imaging and gene expression through RNA or protein detection. Methods can vary from multiplexed immunodetection of multiple protein biomarkers to whole transcriptome analysis of single tissue sections. Generally, both fresh frozen and FFPE tissue sample formats can be accommodated. Other notable features include rapid, automated imaging and integrated analysis software. Browse the spatial biology platforms below to determine which best suits the needs or capabilities of your project.
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Sponsored Products
Akoya Biosciences, a Quanterix company
- Powered by high-speed imaging and proprietary barcoding technology, PhenoCycler®-Fusion 2.0 introduces multi-slide ...
- Protein: 100+
- Barcoded-antibody cyclic staining (reveal-image-remove), ...
- Whole tissue, Single cell, Subcellular
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Bio-Techne Spatial
- COMET™ is a fully-automated, high-throughput, hyperplex platform, designed to obtain scalability and reproducibility ...
- Protein: 40, RNA: 12 with 24 protein (RNAscope HiPlex Pro)
- Sequential immunofluorescence (SeqIF™); automated runs of 40...
- Whole tissue, Single cell, Subcellular
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Bruker Spatial Biology
- The CosMx® Spatial Molecular Imager redefines spatial biology by enabling high-fidelity, single-cell whole-transcriptome...
- RNA: WTx, Protein: 64
- Multiplexed, cyclic FISH; 1000-plex for RNA and 100-plex for...
- ~7–10 days/run (max 14 days)
- Whole tissue, single-cell, subcellular
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Leica Microsystems
- Designed to give users the freedom and confidence to choose exactly how to design and execute their multiplexing ...
- Protein: 60+
- Multiplex immunofluorescence imaging of 60+ biomarkers; ...
- ~12 min/imaging round (1 cm² at 20x)
- Whole tissue, single cell
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Miltenyi Biotec
- The MACSima™ Platform, our revolutionary multiomics solution, streamlines your spatial biology research from end to end,...
- Protein: 200+, RNA: 12 or 24
- Automated cyclic staining, imaging, and erasure (MICS), ...
- ~10 min imaging + 10 min erasure/cycle, ~20 h for 34 cycles
- Whole tissue, Single cell
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RareCyte
- Orion™ Platform is the first and only multiplex immunofluorescence (mIF) platform to enable 20-channel single-round ...
- Protein: 20 (Orion, HT), 14 (LE)
- Single-round 20-channel mIF, multispectral fluorescence with...
- ~75 min/cm² (20x)
- Whole tissue, Single cell
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Stellaromics
- Pyxa is the first platform for true spatial multi-omic analysis of thick tissue sections in 3D. Pyxa is an automated ...
- RNA: custom or off-the-shelf panels
- STARmap™ in situ RNA sequencing, hydrogel-tissue chemistry, ...
- ~14 days (sample prep + instrument)
- Whole tissue, single cell, sub-cellular
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Thermo Fisher Scientific
- The Invitrogen™ EVOS™ S1000 Spatial Imaging can complete the imaging process quickly while generating a fully stitched, ...
- Protein: 8 (+DAPI)
- Spectral fluorescence with unmixing, transmitted, phase, and...
- ~45 min/cm² (9-plex, 20x)
- Whole tissue, Single cell
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TissueGnostics
- Use TissueFAXS Spectra for whole-slide multispectral imaging as well as high-end image analysis. This system allows the ...
- Protein: 8
- Multispectral imaging with LCTF and built-in unmixing, ...
- ~9 min fluorescence, ~1.5 min brightfield (15 × 15 mm, 20x, ...
- Whole tissue, Single cell
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10x Genomics
- Xenium In Situ is the next-level in situ solution for subcellular profiling of 100s of RNA targets, in fresh frozen or ...
- RNA: 100s to 5,000 genes
- In situ probe hybridization, RCA, fluorescent probe ...
- 3 days (up to 480 genes), 6 days (up to 5,000 genes)
- Whole tissue, single-cell, subcellular
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Akoya Biosciences, a Quanterix company
- The PhenoCycler® instrument (formerly CODEX®) is a cutting-edge fluidics control unit that integrates with the ...
- Automated cycling and labeling of analytes for whole-slide ...
- Whole tissue, single cell
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Akoya Biosciences, a Quanterix company
- The PhenoCycler®-Fusion system is the fastest spatial biology solution that enables ultrahigh-plex spatial ...
- Automated cycling and iterative imaging of 100+ biomarkers ...
- Whole tissue, single cell
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Akoya Biosciences, a Quanterix company
- Providing unparalleled speed, performance, and throughput, the PhenoImager® HT instrument integrates the power of ...
- Protein: 6 (Fusion), 8 (HT 2.0)
- Multispectral imaging with onboard spectral unmixing (Opal ...
- Whole tissue, Single cell, Subcellular
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Bruker Daltonics
- The timsTOF fleX is a versatile instrument for probing the molecular content of your sample. The timsTOF fleX is a fully...
- Protein: 100+ (HiPLEX-IHC), untargeted small molecules
- MALDI MS imaging with laser post-ionization (MALDI-2) and ...
- 15 pixels/s
- Whole tissue, Single cell
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Bruker Spatial Biology
- High fidelity, flexible subcellular proteomics for rapid and quantitative spatial phenotyping
The CellScape™ XR... - Protein: high-plex
- Highly multiplexed immunofluorescence of multiple protein ...
- Whole tissue, single-cell, subcellular
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Bruker Spatial Biology
- Experience discovery-scale spatial multiomics with the GeoMx Digital Spatial Profiler (DSP). GeoMx DSP enables high-plex...
- RNA: WTx (WTA), Protein: 1,200+ (DPA)
- Barcoded antibodies or RNA probes, UV-cleaved barcodes from ...
- ~2 h setup and scan + 3.6 h collection (4 slides)
- Whole tissue
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Shimadzu
- The iMScope QT Imaging Mass Microscope is a combination of an optical microscope and an AP-MALDI ion source enabling ...
- Untargeted small molecules
- AP-MALDI imaging under an optical microscope, Q-TOF MS (LCMS...
- 50 pixels/s (high-speed mode), ~1–4 h/cm²
- Whole tissue
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Standard BioTools Inc.
- The Hyperion+™ Imaging System uses Imaging Mass Cytometry™ (IMC™) to visualize the complex spatial biology of the ...
- Imaging mass cytometry (CyTOF) using mass-tagged antibodies;...
- Whole tissue, single cell
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10x Genomics
- Atera offers a 625 mm² imageable area per slide, or 2,500 mm² of total tissue per run when all four slides are used, and...
- RNA: WTx (18,000+ genes) or 1,000–2,000-gene panels
- In situ probe hybridization, RCA, cyclic multichannel ...
- ~7 days/WTx run, plus 2–3 days sample prep
- Whole tissue, Single cell, Subcellular
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10x Genomics
- Visium Spatial Gene Expression is a next-generation molecular profiling solution for classifying tissue based on total ...
- Slide-based mRNA capture and sequencing to analyze the whole...
- Whole tissue, single cell
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Advanced Cell Diagnostics
- RNAscope Technology is a novel in situ hybridization (ISH) assay for detection of target RNA within intact cells. The ...
- In situ hybridization (ISH) assay - single to 12-plex
- Whole tissue, single cell
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Bruker Daltonics
- The Bruker neofleX is a benchtop axial MALDI-TOF/TOF mass spectrometer that supports both MALDI Imaging and MS/MS ...
- Protein: 116 (HiPLEX-IHC), untargeted small molecules
- Benchtop MALDI MS imaging, TOF/TOF detection
- Up to 20 pixels/s
- Whole tissue
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Leica Microsystems
- The Autiva Spatial Phenotyper is an automated, open spatial biology platform that integrates cyclic immunofluorescence ...
- Protein: 60+
- Automated cyclic mIF, microfluidic stain-image-destain ...
- ~48 h for 60 markers on 4 slides (15 × 15 mm)
- Whole tissue, Single cell
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Singular Genomics
- High-throughput in-situ spatial sequencing for transcriptomic and proteomic analysis from FFPE samples at subcellular ...
- RNA: up to 500 genes, Protein: 18, fluorescent H&E
- In situ SBS with padlock-probe detection of RNA and protein,...
- 12–24 h/run
- Whole tissue, Single cell, Subcellular
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Oregon Physics
- The MIBIscope™ by Oregon Physics is a spatial proteomics platform based on secondary ion mass spectrometry (SIMS) that ...
- Protein: 40+
- MIBI with metal-isotope-tagged antibodies, TOF mass ...
- 35 min (1 µm), 68 min (500 nm), 139 min (350 nm) per 800 × ...
- Single cell, Subcellular
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Select up to 5 products from above to compare or request more information.
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