Anti-CD8A antibodies are used in the immunodetection of the protein CD8 subunit alpha. In humans, the canonical protein has a reported length of 235 amino acid residues and a mass of 25.7 kDa. Its subcellular localization is in the cell membrane. Up to 3 different isoforms have been reported for this protein. It is notably expressed in the spleen, skin, lymph node, bone marrow, and appendix. CD8A is known to be involved with adaptive immune responses and receptor-mediated signaling pathways. Post-translational modifications have been described, including O-glycosylation, palmitoylation and phosphorylation.
The CD8A marker can be used to identify Mature CD8 T Cells, Lymphocytes, CD8 ?a+ ?ß Intraepithelial T Cells, CD8 ?a+ Gamma-Delta Intraepithelial T Cells, and CD8 ?ß+ ?ß Intraepithelial T Cells.* Synonyms for this target antigen include CD8alpha, Leu2, p32, T-cell surface glycoprotein CD8 alpha chain, CD8 antigen, alpha polypeptide (p32), and CD8. CD8A gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4