Anti-SOX2 antibodies are used in the immunodetection of the protein SRY-box transcription factor 2. In humans, the canonical protein has a reported length of 317 amino acid residues and a mass of 34.3 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is notably expressed in many tissues, such as the bronchus and esophagus. SOX2 is reported to be a transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Post-translational modifications have been described, including sumoylation. The SOX2 marker can be used to identify Amnion Epithelial Cells (AEC).* Synonyms for this target antigen include MCOPS3, transcription factor SOX-2, SRY (sex determining region Y)-box 2, SRY-box 2, SRY-related HMG-box gene 2, and ANOP3. SOX2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4