SOX2 Antibody AF2018 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemSOX2 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $499.00Supplier Page View Company Product Page
Catalog NumberAF2018
ApplicationsBioassay,Binding Assay,Co-Immunoprecipitation,IF/ICC,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Dot Blot,Mass Spectrometry,Simple Western,Immunofluorescence,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry,RNAscope compatible,Immunocytochemistry/ Immunofluorescence
IsotypeIgG
Quantity100 ug (also 25 ug)
Conjugate/TagUnconjugated
ReactivityAvian - Chicken,Avian - Quail,Bovine,Canine,Chicken,Ferret,Fish,Human,Mouse,Porcine,Primate - Callithrix jacchus (Common Marmoset),Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque),Primate - Macaca mulatta (Rhesus Macaque),Primate - Pan troglodytes (Chimpanzee),Rabbit,Rat,Transgenic Mouse,Xenograft,Xenopus,Zebrafish,Fish - Danio rerio (Zebrafish),Frog - Xenopus (African Clawed Frog),Insect - Aedes albopictus (Asian tiger mosquito)
HostGoat
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
TargetSOX2
ClonalityPolyclonal
ImmunogenE. coli-derived recombinant human SOX2, Gly135-Met317, Accession # P48431
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects human SOX2 in direct ELISAs and Western blots.

Sizes Available: 100 ug (also 25 ug)

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Questions and Answers

Can this SOX2 antibody be used for ChIP-seq experiments?

Yes, the SOX2 antibody from R&D Systems has been utilized in chromatin immunoprecipitation sequencing (ChIP-seq) experiments, as demonstrated in studies where it was used to analyze SOX2 interactions in mouse embryonic stem cells and differentiated neurons ().

What applications has this antibody been shown to work in?

The SOX2 antibody has been shown to work in various applications including Western blotting, immunofluorescence, immunohistochemistry, and chromatin immunoprecipitation, among others (, ).

Is this antibody effective for detecting SOX2 in human tissues?

Yes, the SOX2 antibody has been specifically noted for its ability to detect human SOX2 in direct ELISAs and Western blots, confirming its effectiveness in human tissue applications ().

What role does SOX2 play in stem cell research, and how has this antibody been utilized in that context?

SOX2 is a critical regulator of pluripotency and has been implicated in various differentiation processes. The antibody has been used to study its role in maintaining stemness in neuroblastoma cells and in the differentiation of embryonic stem cells into neurons, highlighting its importance in stem cell biology (, ).

R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) A neural stem cell–derived 3D spheroid model that recapitulates prion infection and pathologyMaterials Today BioAugust 1, 2026Hyun Jung Park, Hyeri Kim, Sanghoon Byun, Chongsuk RyouImmunofluorescence),Thermo Fisher Scientific,Cat#13-1500; RRID: AB_2533001 SOX2 (for Immunofluorescence),R&D Systems,Cat#AF2018; RRID: AB_355110 Nestin (for Immunofluorescence),R&D Systems,Cat#MAB1259; RRID: AB_2251304 Tuj-1 (for

(2) Clinical, cellular, and genomic consequences of a population-enriched SETD1A missense variantResearchSquareJuly 13, 2026Robert Ament, Rediet T. Oshone, Rediet Oshone, Samaneh Ahmed, Sterling Arjona, Sterling Arjona, Jayme Colantuoni, Marcia Cortes-Gutierrez, Brian R. Cortes-Gutierrez, Elizabeth M. Humphries, et al.diluted in PBS and 1% BSA. Primary antibodies include: SOX2 (1:200 dilution, R&D Systems, Catalog # AF2018); ZO-1/TJP1-FITC (1:250 dilution, INVITROGEN, Catalog # 339111); SOX1 (1:250 dilution, BD Biosciences,

(3) Persistent and transient senescent cells contribute to brain-barrier developmentCellJuly 9, 2026L. Ashley Watson, Zoe Adelsheim, Mackenzie J. Carter, Grace T. Carter, Karen L. Jimenez-Reyes, Huijie Du, Ziqing Zhu, David B. Berry, Mia C. Paredez, Rania H. Palaniappan, et al.AB_2297123" Rabbit anti-Tbr2,Abcam,"Cat# ab216870, RRID: AB_2943124" Goat anti-Sox2,R&D Systems,"Cat# AF2018, RRID: AB_355110" Rabbit anti-ZO-1,Invitrogen,"Cat# 617300, RRID: AB_138452" Sheep anti-Plxnb2,R&D Systems

(4) Human amygdala-like telencephalic organoids model stress circuitry in assembloid systemsCell Stem CellJuly 2, 2026Woo Sub Yang, Mu Seog Choe, Cynthia Lo, Hui-Wen Liu, Yoon Mi Cho, Jonghun Kim, Ferdi Ridvan Kiral, Michael Scandura, Xiaona Lu, Kun-Yong Kim, et al.(1:200; bs-0252R-TR, Bioss), rabbit anti-PSD95 (1:100; 51-6900, Thermo Fisher), goat anti-SOX2 (1:200; AF2018, R&D Systems), mouse anti-MAP2 (1:200; MAB3418, Millipore Sigma), rabbit anti-DLX2 (1:100; AB135620,

(5) TGFβ signalling maintains Sox4+ astrocyte progenitors and restricts the early differentiation of BLBP+ astrocytes in the mouse dentate gyrusFrontiers in Cellular NeuroscienceJuly 1, 2026Kyoji Ohyama, Shoichiro Omura, Natsumi Takayama, Tokiharu Takahashi1:1,000); mouse anti- phosphorylated vimentin (pVim) (MBL, D076-3S, 1:250); goat anti-Sox2 (R&D systems, AF2018, 1:1,000); rabbit anti-Sox3 serum (gift from T. Edlund, 1:1,000); rabbit anti-Sox4 (Millipore, AB5803,

(6) MAPK/ERK signaling regulates H3K9me3 heterochromatin reorganization to confer mesendoderm developmental competenceNucleic Acids ResJune 27, 2026Satoshi Matsui, Samuel Sampson, Gerardo Mirizio, Marissa Granitto, Ryo Maeda, Makoto Tachibana, Christopher Ahn, Hee-Woong Lim, Makiko IwafuchiAntigen,Supplier,Cat no.,Lot no.,Host,Dilution factor OCT4,DSHB,PCRP-POU5F1-1D2,N/A,Mouse,1:20 SOX2,R&D Systems,AF2018,KOY0419101,Goat,1:1000 SOX2,Cell Signaling,4900S,5,Mouse,1:500 SOX1,Cell Signaling,4194S,2,Rabbit,1:1000 ,,,,,1:250 TBXT,R&D Systems

(7) Circadian-Related Serotonin/Melatonin Level Modulates Cisplatin Ototoxicity Susceptibility Depended on NOS3-NO PathwayJ Pineal ResJune 9, 2026Siyu Qiu, Shiyi Cai, Rong Xie, Chang Liu, Yingzi HeR‐HRP, Proteus BioSciences), chicken anti‐Neurofilament (1:500, ab254348, Abcam), goat anti‐SOX2 (1:500, AF2018, R&D Systems), mouse anti‐β‐III‐tubulin (Tuj1, IgG2a; 1:500, 801202, BioLegend), rabbit anti‐Homer1

(8) Spatially resolved transcriptomics identifies intercellular signaling post-ischemic stroke that controls neural stem cell proliferationStem Cell ReportsJune 9, 2026He Huang, Emerson Daniele, Wing Chung Jessie Lam, Teodora Tockovska, Daniela Lozano Casasbuenas, Hathairat Chanphao, Bebhinn Treanor, Maryam Faiz, Scott A. Yuzwa(Cell Signaling Technology, Cat#3728S, RRID: AB_2194037) at 1:250 dilution; goat anti-SOX2 (R&D Systems, Cat#AF2018, RRID: AB_355110) reconstituted at 1 mg/mL in sterile PBS and diluted at 1:100; mouse anti-GFAP (Cell Signaling Technology

(9) NR3C1 is required for normal somatotrope differentiation and Foxo1 expression in pituitaryEndocrinologyMay 26, 2026Pratyusa Das, Ridwanullah A Abubakar, Nooshin Mojahed, Dania Abou-Jabal, Prisha Kittu, Michelle L Brinkmeier, Jessica Olsen, Dale Ann Sunny, Sally A Camper, Robin Lovell-Badge, et al.Guinea pig anti-rat LHB,AB_2665565,LHB,NHPP,AFP22238790GPOLHB,1:500 Goat anti-SOX2,AB_355110,SOX2,Biotechne,AF2018,1:500 Anti-human FOXL2,AB_3730166,FOXL2,Reiner A. Veitia,ALT_C-hFOXL2,1:500 Antibody information Abbreviations:

(10) Disrupting SOX2 self-association and condensate formation to overcome chemotherapeutic drug resistance in lung squamous cell carcinomaSignal Transduct Target TherMay 13, 2026Juehan Wang, Yulin Wen, Sainan Huang, Yanjiang Liu, Xiaotao Dong, Hongmo Liu, Zhihua Guo, Jin Li, Chengzhi Zhou, Hua Wang, et al.pretreatment and incubated for 10 min. Bead-bound cells were incubated with SOX2 antibody (R&D Systems, AF2018) in 100 μL antibody buffer at 4 °C overnight. The supernatant was discarded, and the magnetic beads

(11) Micro S plit : semantic unmixing of fluorescent microscopy dataNat MethodsMay 5, 2026Ashesh Ashesh, Federico Carrara, Igor Zubarev, Vera Galinova, Melisande Croft, Melissa Pezzotti, Daozheng Gong, Francesca Casagrande, Elisa Colombo, Stefania Giussani, et al.the blocking solution overnight at 4 °C. The following antibodies were used: SOX2 (goat polyclonal, AF2018, 1:200 dilution, R&D Systems) and GRASP65 (rabbit polyclonal, PA3-910, 1:200, Invitrogen). Subsequently,

(12) Multiomics analysis identifies VPA-induced changes in neural progenitor cells, ventricular-like regions, and cellular microenvironment in dorsal forebrain organoidsMolecular PsychiatryApril 24, 2026Zeynep Yentür, Lizia Branco, Kseniia Sarieva, Daria Andreeva, Theresa Kagermeier, Christina Kulka, Mohamed A. Jarboui, Federico Colombo, Florencia Diaz, Pierre Collignon, et al.(anti-Ki-67 (rabbit, 1:300, Merck, Cat. no. AB9260), anti-SOX2 (goat, 1:500, R&D Systems, Cat. no. AF2018), anti-CTIP2 (rat, 1:400, Abcam, Cat. no. ab18465), and anti-cCas3 (rabbit, CST, Cat. no. 9661S) anti-PAX6

(13) ChREBPα: a central metabolic sensor driving lipid droplet renewal in preimplantation mouse embryosFrontiers in Cell and Developmental BiologyApril 23, 2026Abdul Majid Khan, Dawid Winiarczyk, Francesca Boffa, Dominika Żbikowska, Luca Palazzese, Silvestre Sampino, Domenico Iusoapplied at a 1:100 dilution in 10% donkey serum. The following antibodies were used: goat anti-SOX2 (Cat# AF2018, RRID:AB_355110, R&D Systems, USA), mouse anti-CDX2 (Cat# MU392A-UC, RRID:AB_3101998, BioGenex, USA),

(14) Phaeochromocytomas and paragangliomas harbour tumour-initiating SOX2+ stem cellsEndocr Relat CancerApril 22, 2026Yasmine Kemkem, Mark Quinn, Bence Kövér, Alice Santambrogio, James Kaufman-Cook, Olivia Sherwin, Laura D Scriba, Dimitria Brempou, Miriam Vazquez Segoviano, Dylan Cameron, et al.buffer (mouse anti-tyrosine hydroxylase (CAT# 612300, BD Biosciences, USA, 1:500 – goat anti-SOX2 (CAT# AF2018, R&D Systems, USA, 1:500)) and a 1 h incubation in fluorophore-conjugated secondary antibodies (Biotinylated

(15) Human promoter-driven AAV tools enable precision gene therapy targeting cochlear hair cellsCell Reports MedicineApril 21, 2026Liyan Zhang, Yicheng Lu, Xianmin Wu, Jinyi Fan, Xinru Zhang, Yang Xu, Hao Wei, Qiuhan Sun, Lulu Jiang, Huawei Tuo, et al.Cat#HPA020899), anti-Myo7a (rabbit, Proteus Bioscience, Cat#25–6790), anti-Sox2 (goat, R&D systems, Cat#AF2018), Anti-Otoferlin (C-terminal, rabbit, Thermo Scientific, Cat#PA552935), Anti-Otoferlin (N-terminal,

(16) Dysregulation of Hippo Signaling Pathway as a Convergent Mechanism Underlying Choroid Plexus Defects in Bipolar DisorderbioRxivApril 10, 2026Jonghun Kim, Mu Seog Choe, Kutlu Kaya, Yue Hu, Kenneth K. Ng, Caihong Qiu, Mei Zhong, Woo Sub Yang, Ferdi Ridvan Kiral, Cynthia Lo, et al.microscope (Leica Microsystems). The following primary antibodies were used in this study: Goat anti-SOX2 (AF2018, R&D Systems), Mouse anti-TTR (MAB7505, R&D Systems), Rabbit anti-LMX1A (PA5–115517, Invitrogen), Rabbit

(17) Targeting Tumour Microtubes to Disrupt Glioma NetworksResearch SquareApril 7, 2026Tengfei Huang, Tengfei Huang, Suchet Zhang, Suchet Taori, Donghai Wang, Donghai Wang, Huairui Chen, Huairui Yuan, Tingting Duan, Tingting Duan, et al.AB_3635893), FASTKD2 (Rabbit, NOVUS, Cat# NBP1–55360, 1:1000, RRID: AB_11030882), SOX2 (Goat, NOVUS, Cat# AF2018, 1:500, RRID: AB_355110), YTHDF3 (Rabbit, NOVUS, Cat# NBP3–25764, 1:500, RRID: AB_3635894), METTL3 (Rabbit,

(18) ADNP missense variant p.C687R disrupts chromatin regulation and GABAergic differentiation in Helsmoortel-Van der Aa syndromeMol AutismApril 6, 2026Qi Chen, Xixi Liu, Mengnan Wu, Daijing Sun, Xingyu Ding, Mengling Zhou, Wenzhu Peng, Yan Cheng, Biqing Xue, Ning Tang, et al.4 °C with primary antibodies: anti-NKX2.1 (Millipore, MAB5460, 1:1000) and anti-SOX2 (R&D Systems, AF2018, 1:800) diluted with 0.1% DPBST containing 5% normal donkey serum. After washing 3 times, slices were

(19) Driving Naive State Induction Using Human Wharton Jelly-Mesenchymal Stem Cell-Derived Conditioned Medium in Rhesus Monkey Embryonic Stem CellsCellsMarch 31, 2026Preeyanan Anwised, Ratree Moorawong, Worawalan Samruan, Jittanun Srisutush, Sirilak Somredngan, Irene Aksoy, Pierre Savatier, Rangsun Parnpai"Cell Signaling Technology (Danvers, MA, USA) #4903S" Primary Ab,Goat anti-SOX2,1:200,"R&D Systems (Minneapolis, MN, USA) #AF2018" Primary Ab,Rabbit anti-TBXT,1:100,"Cell Signaling Technology (Danvers, MA, USA) #81694S" Primary

(20) Epithelial-Mesenchymal Wnt Crosstalk Directs Planar Cell Polarity in the Developing CochleabioRxivMarch 31, 2026Ippei Kishimoto, Abel P. David, Kevin P. Rose, Balasubramanian Narasimhan, Bradley Efron, Sara E. Billings, Erin L. Su, Wuxing Dong, Taha A. Jan, Ronna Hertzano, et al.counterstained with anti-Myosin7a (rabbit, 1:1000, 25-6790, Proteus Bioscience) and Sox2 (goat, 1:200, AF2018, R&D Systems) antibodies. The use of these antibodies was done according to the manufacturer’s instructions

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(1)

10/6/2020Immunostaining with Sox2 Antibody Bhavin ShahAdult mouse brain tissue was stained with SOX2 antibody to determine the neural stem cell population.
(1)

9/11/2020Goat Anti-Sox2 Antibody for Immunofluorescence José VieiraAntibody used to label neural progenitors in the developing spinal cord.
(1)

8/8/2019Good SOX2 Antibody for Glial Cells from R&DDr. David SunnenHighly recommend as a glial marker in central nerve system.

SOX2 Antibody

SOX2 Antibody

SOX2 Antibody

SOX2 Antibody

SOX2 Antibody

SOX2 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

Questions and Answers

R&D Systems, a Bio-Techne Brand

Citations (552)

Reviews

SOX2 Antibody from R&D Systems, a Bio-Techne Brand

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