Anti-CAV1 antibodies are used in the immunodetection of the protein caveolin 1. In humans, the canonical protein has a reported length of 178 amino acid residues and a mass of 20.5 kDa. Its subcellular localization is in the Golgi and cell membrane. It is notably widely expressed in many tissue types. A member of the Caveolin protein family, CAV1 is believed to act as a scaffolding protein within caveolar membranes. Post-translational modifications have been described, including ubiquitination, acetylation and phosphorylation.
The CAV1 marker can be used to identify Deep-Layer Corticothalamic And 6B Neurons, Blood Vessel Endothelial Cells, Lymphatic Vessel Endothelial Cells, and Subcapsular Sinus Ceiling Lymphatic Endothelial Cells.* Synonyms for this target antigen include CGL3, LCCNS, MSTP085, PPH3, VIP21, caveolin 1, caveolae protein, 22kDa, cell growth-inhibiting protein 32, and BSCL3. CAV1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 780 citations in the literature describe the use of CAV1 antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4