Anti-IL17RA antibodies are used in the immunodetection of the protein interleukin 17 receptor A. In humans, the canonical protein has a reported length of 866 amino acid residues and a mass of 96.1 kDa. Its subcellular localization is in the cell membrane and is secreted. Up to 2 different isoforms have been reported for this protein. It is widely expressed across many tissue types. IL17RA is a known receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Post-translational modifications have been described, including glycosylation. The IL17RA gene has been associated with the disease, Immunodeficiency. Synonyms for this target antigen include CD217, CDw217, IL17R, IMD51, hIL-17R, IL-17 receptor A, and CANDF5. IL17RA gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.