Mouse IL-17RA/IL-17R Antibody MAB4481 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemMouse IL-17RA/IL-17R Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $479.00Supplier Page View Company Product Page
Catalog NumberMAB4481
TargetIL-17RA/IL-17R
HostRat
NCBI Full Gene Nameinterleukin 17 receptor A
NCBI Gene AliasesVDw217, Cdw217, Il17r
ReactivityHu, Ms, Rt
ClonalityMonoclonal
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse IL-17 RA/IL-17 R, Ser32-Trp322, Accession # Q60943
ConcentrationLYOPH
PurityProtein A or G purified from hybridoma culture supernatant
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution
Antibody TypePrimary Antibodies
ApplicationsWB, FCM, IHC, FA, MC, Neut
Clone657603
Conjugate/TagUnconjugated
IsotypeIgG2a
Quantity100 ug (also 25 ug)

Specifications/Features

Available conjugates: Unconjugated

Questions and Answers

Can this antibody be used to study the role of IL-17RA in lung cancer models?

Yes, the IL-17RA/IL-17R Antibody has been utilized in studies investigating the role of IL-17A in lung tumor progression. For instance, in a study by Akbay et al. (2017), the antibody was employed to analyze immune phenotyping in mouse lung models, demonstrating the involvement of IL-17A in promoting tumor growth and influencing immune responses.

Is there evidence that blocking IL-17RA can enhance the efficacy of immune checkpoint inhibitors?

Yes, research by Hu et al. (2024) indicates that neutralizing IL-17RA can improve the outcomes of immune checkpoint inhibitors by reducing immune-related adverse events while also exhibiting antitumor activity. This suggests that targeting IL-17RA may be beneficial in optimizing cancer immunotherapy.

How specific is this antibody for mouse IL-17RA compared to human IL-17RA?

The IL-17RA/IL-17R Antibody is highly specific for mouse IL-17RA, showing no cross-reactivity with recombinant human IL-17RA or other related receptors in direct ELISAs and Western blots. This specificity is crucial for accurate experimental results when studying mouse models.

Has this antibody been cited in studies related to inflammatory bowel disease and its complications?

Yes, the IL-17RA/IL-17R Antibody has been referenced in studies examining the role of IL-17RA in inflammatory bowel disease. For example, Saleh et al. (2019) utilized this antibody to investigate the effects of IL-17RA blockade on Th17 cell responses and their implications in Clostridium difficile infection following colitis.

R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Anti-PD-L2 immunotherapy is efficacious against melanoma in aged hosts through IL-17 and IFNγ signallingNature CommunicationsNovember 19, 2025Carlos O. Ontiveros, Myrna G. Garcia, Clare E. Murray, Yilun Deng, Haiyan Bai, Christopher Tanner, Bernice Leung, Xin Li, Alvaro Padron, Ryan M. Reyes, et al.and tumours were monitored and harvested for flow cytometry as above. αIL-17R (R&D Systems catalog # MAB4481) was administered on day 18 (25 μg/mouse i.p.). In vivo tumour growth monitoring Subcutaneous tumour

(2) Innovative peptide therapeutics targeting IL17RA to regulate inflammatory responsesScientific reportsMarch 22, 2025Wang X, Bao H, Wang Y, Wang Y, Guo C, Wu Y, Xu Y, Li Y.were incubated with 100 nM AL-8(0) or 100 nM anti-IL17RA functional antibody (R&D Systems, MAB177 /MAB4481, USA) at 37 °C for 30 min. Subsequently, IL17RA-expressing or IL17RA-deficient cells were co-cultured

(3) Spinal astrocyte-derived interleukin-17A promotes pain hypersensitivity in bone cancer miceActa Pharmaceutica Sinica BDecember 1, 2024Huizhu Liu, Xuejing Lv, Xin Zhao, Lanxing Yi, Ning Lv, Wendong Xu, Yuqiu ZhangIL-17A antibody (sc-374218) and control IgG (sc-2025) from Santa Cruz, the mouse IL-17RA antibody (MAB4481) and control IgG (MAB006) from R&D system, and the rabbit CX3CR1 antibody (TP501) and control IgG (PP501P)

(4) Annexin 1 Reduces Dermatitis-Induced Itch and Cholestatic Itch through Inhibiting Neuroinflammation and Iron Overload in the Spinal Dorsal Horn of MiceBrain sciencesApril 28, 2024Li T, Hu L, Qin C, Li Y, Song Z, Jiao Y, Wang C, Cui W, Zhang L.Cat. sc-374218) was from Santa Cruz Biotechnology (Dallas, TX, USA). IL-17R antibody (IL-17R Ab; Cat. MAB4481) was from R&D Systems (Minneapolis, MN, USA). The rationale that choosing dosages of these reagents

(5) Inhibition of IL-25/IL-17RA improves immune-related adverse events of checkpoint inhibitors and reveals antitumor activityJournal for immunotherapy of cancerMarch 21, 2024Hu X, Bukhari SM, Tymm C, Adam K, Lerrer S, Henick BS, Winchester RJ, Mor A.IL-25 antibody,Lanier Biotherapeutics,LNR125 and LNR125.38 Mouse IL-17RA/IL-17R Antibody,R&D Systems,MAB4481 Flow/IHC Antibodies,Flow/IHC Antibodies,Flow/IHC Antibodies Alexa Fluor 488 anti-mouse CD3,BioLegend,100210 Brilliant Violet 510 anti-mouse CD4

(6) Glia-derived adenosine in the ventral hippocampus drives pain-related anxiodepression in a mouse model resembling trigeminal neuralgiaBrain, behavior, and immunityMarch 1, 2024Lv XJ, Lv SS, Wang GH, Chang Y, Cai YQ, Liu HZ, Xu GZ, Xu WD, Zhang YQ.

(7) CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathologyNature immunologyNovember 1, 2022Knizkova D, Pribikova M, Draberova H, Semberova T, Trivic T, Synackova A, Ujevic A, Stefanovic J, Drobek A, Huranova M, et al.Sigma-Aldrich; ACT1 (sc-398161) and p38 (sc-728) were from Santa Cruz Biotechnology; murine IL-17RA (MAB4481), IL-17RC (AF2270), IL-17RD (AF2276) and TNFR1 (AF-425-PB) were from R&D Systems; and TRAF6 (ab40675)

(8) Minocycline reverses IL-17A/TRAF3IP2-mediated p38 MAPK/NF-κB/iNOS/NO-dependent cardiomyocyte contractile depression and deathCellular signallingSeptember 1, 2020Yoshida T, Das NA, Carpenter AJ, Izadpanah R, Kumar SA, Gautam S, Bender SB, Siebenlist U, Chandrasekar B.

(9) Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile InfectionCell host & microbeMay 8, 2019Saleh MM, Frisbee AL, Leslie JL, Buonomo EL, Cowardin CA, Ma JZ, Simpson ME, Scully KW, Abhyankar MM, Petri WA Jr.IL-17A neutralization: DSS-treated mice were injected i.p. with 125μg α-IL-17RA (R&D Systems, Cat# MAB4481, RRID:AB_10891109), 125μg αIL-17A (R&D Systems, Cat# MAB421, RRID:AB_2125018) or IgG isotype control

(10) Interleukin-17A participates in podocyte injury by inducing IL-1β secretion through ROS-NLRP3 inflammasome-caspase-1 pathwayScandinavian journal of immunologyApril 1, 2018Yan J, Li Y, Yang H, Zhang L, Yang B, Wang M, Li Q.

(11) Interleukin-17A Promotes Lung Tumor Progression through Neutrophil Attraction to Tumor Sites and Mediating Resistance to PD-1 BlockadeJournal of thoracic oncology : official publication of the International Association for the Study of Lung CancerAugust 1, 2017Akbay EA, Koyama S, Liu Y, Dries R, Bufe LE, Silkes M, Alam MM, Magee DM, Jones R, Jinushi M, et al.and anti-mouse IL-17RA antibodies were purchased from PeproTech (200-17 and 210-17) and R&D systems (MAB4481) respectively, and used at the doses indicated in the figure based on manufacturers’ instruction. Bronchoalveolar lavage

(12) Blocking IL-17A Alleviates Diabetic Retinopathy in RodentsCellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacologyJanuary 1, 2017Qiu AW, Liu QH, Wang JL.

(13) Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 functionProceedings of the National Academy of Sciences of the United States of AmericaOctober 11, 2016Ippagunta SK, Gangwar R, Finkelstein D, Vogel P, Pelletier S, Gingras S, Redecke V, Häcker H.

(14) Galectin-3 negatively regulates dendritic cell production of IL-23/IL-17-axis cytokines in infection by Histoplasma capsulatumJournal of immunology (Baltimore, Md. : 1950)April 1, 2013Wu SY, Yu JS, Liu FT, Miaw SC, Wu-Hsieh BA.

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IL-17RA/IL-17R Antibody

IL-17RA/IL-17R Antibody

IL-17RA/IL-17R Antibody

IL-17RA/IL-17R Antibody

IL-17RA/IL-17R Antibody

Mouse IL-17RA/IL-17R Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

Questions and Answers

R&D Systems, a Bio-Techne Brand

Citations (14)

Reviews

Mouse IL-17RA/IL-17R Antibody from R&D Systems, a Bio-Techne Brand

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