Anti-SIRPA antibodies are used in the immunodetection of the protein signal regulatory protein alpha. In humans, the canonical protein has a reported length of 504 amino acid residues and a mass of 55 kDa. Its subcellular localization is in the membrane. Up to 3 different isoforms have been reported for this protein. It is ubiquitously expressed across many tissue types. SIRPA is known to be involved with cell adhesion and cell migration. Post-translational modifications have been described, including N-glycosylation and phosphorylation. The SIRPA marker can be used to identify CDC2 CD1C+ Myeloid Dendritic Cells.* Synonyms for this target antigen include CD172 antigen-like family member A, brain-immunoglobulin-like molecule with tyrosine-based activation motifs, inhibitory receptor SHPS-1, and tyrosine-protein phosphatase non-receptor type substrate 1. SIRPA gene orthologs have been reported in the mouse, bovine and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4