Anti-MMP9 antibodies are used in the immunodetection of the protein matrix metallopeptidase 9. In humans, the canonical protein has a reported length of 707 amino acid residues and a mass of 78.5 kDa. Its subcellular localization is in the extracellular matrix and is secreted. It is notably expressed in neutrophils. A member of the Peptidase M10A protein family, MMP9 is reported to be a matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Post-translational modifications have been described, including O-glycosylation. The MMP9 marker can be used to identify Neutrophils.* Synonyms for this target antigen include GELB, MANDP2, matrix metalloproteinase-9, macrophage gelatinase, and CLG4B. MMP9 gene orthologs have been reported in the mouse, rat, bovine, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4